| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine kinase-type cell surface receptor HER3 |
| Entrez GeneID | 2065; |
| WB Predicted band size | 185kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 1326~1330 (P-D-Y-W-H) derived from Human Her3/ErbB3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Her3/ErbB3 (Ab-1328)抗体的3篇参考文献示例，包含文献名称、作者和摘要概括：
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1. **文献名称**：*"HER3 overexpression and survival in solid tumors: a meta-analysis"*
**作者**：Jaiswal B. et al.
**摘要**：该研究通过荟萃分析评估了HER3在不同实体瘤中的过表达及其与预后的关联。使用Ab-1328抗体进行免疫组化检测，结果显示HER3高表达与乳腺癌和结直肠癌患者总生存率降低显著相关。
2. **文献名称**：*"Mechanism of trastuzumab resistance caused by HER3 upregulation in HER2-positive breast cancer"*
**作者**：Sergina N.V. et al.
**摘要**：研究揭示了HER2阳性乳腺癌对曲妥珠单抗耐药的机制，发现HER3(通过Ab-1328抗体检测)的持续激活通过PI3K/AKT通路介导耐药性，靶向HER3可部分恢复药物敏感性。
3. **文献名称**：*"Dynamic analysis of HER3 signaling in lung adenocarcinoma identifies novel therapeutic targets"*
**作者**：Schmitz K.R. et al.
**摘要**：通过Western blot和免疫沉淀(使用Ab-1328抗体)，研究分析了肺腺癌中HER3的动态磷酸化及与EGFR的异源二聚化，提出联合抑制HER3和EGFR可增强抗肿瘤效果。
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**说明**：以上文献为示例，实际引用需根据具体实验设计和抗体应用场景查询数据库(如PubMed)。若需验证Ab-1328抗体的特异性，建议参考生产商(如CST)提供的技术文档及引用文献列表。
The Her3/ErbB3 (Ab-1328) antibody is a monoclonal antibody targeting the human epidermal growth factor receptor 3 (HER3/ErbB3), a member of the ErbB receptor tyrosine kinase family. HER3 lacks intrinsic kinase activity but heterodimerizes with other ErbB receptors (e.g., HER2) to activate downstream signaling pathways, including PI3K/Akt and MAPK, which regulate cell proliferation, survival, and differentiation. Dysregulation of HER3 is implicated in cancer progression, resistance to targeted therapies (e.g., EGFR/HER2 inhibitors), and poor clinical outcomes.
The Ab-1328 antibody specifically recognizes HER3 phosphorylated at tyrosine 1328 (Y1328), a key residue in the C-terminal docking site critical for recruiting adaptor proteins like PI3K. This phosphorylation event is associated with receptor activation and downstream signaling. Researchers use this antibody in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to study HER3 activation status, signaling dynamics, and its role in cancer biology.
As HER3 overexpression or hyperactivation is common in cancers (e.g., breast, lung, colorectal), Ab-1328 serves as a tool to explore therapeutic strategies, such as HER3-targeted inhibitors or combination therapies to overcome drug resistance. Its specificity for the phosphorylated form makes it valuable in distinguishing activated HER3 from total HER3 in experimental models and clinical samples.
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