| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | STMN1; STN1; stathmin |
| Entrez GeneID | 3925; |
| WB Predicted band size | 19kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 23~27 (I-L-S-P-R) derived from Human Stathmin 1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Stathmin1(Ab-25)抗体的示例参考文献(注：以下为模拟示例，建议通过学术数据库验证具体文献)：
1. **文献名称**：*"Phosphorylation of Stathmin1 at Serine 25 by CDK1 promotes cancer cell motility and invasion"*
**作者**：Li, X., et al.
**摘要**：研究利用Stathmin1(Ab-25)抗体特异性检测Ser25磷酸化位点，发现其在乳腺癌细胞迁移和侵袭中的关键作用，揭示CDK1介导的磷酸化调控机制。
2. **文献名称**：*"Stathmin1 phosphorylation dynamics in neuronal development and degeneration"*
**作者**：Smith, J.R., et al.
**摘要**：通过Stathmin1(Ab-25)抗体分析磷酸化水平，发现神经元分化过程中Ser25位点的去磷酸化与轴突再生能力相关，为神经退行性疾病提供潜在靶点。
3. **文献名称**：*"Aberrant Stathmin1 expression in ovarian cancer: Correlation with chemoresistance via Ab-25 epitope recognition"*
**作者**：Garcia, M., et al.
**摘要**：使用Stathmin1(Ab-25)抗体进行免疫组化分析，证实卵巢癌组织中Stathmin1高表达与顺铂耐药性显著相关，提示其作为预后标志物的价值。
4. **文献名称**：*"Role of Stathmin1 phosphorylation in microtubule regulation during mitosis"*
**作者**：Chen, Y., et al.
**摘要**：通过Stathmin1(Ab-25)抗体结合免疫荧光技术，揭示有丝分裂中Ser25磷酸化对微管稳定性的调控作用，影响细胞周期进程。
建议通过PubMed或Google Scholar以关键词“Stathmin1 Ab-25 antibody”或“Stathmin1 Ser25 phosphorylation”进一步检索真实文献。
**Background of Stathmin1 (Ab-25) Antibody**
Stathmin1. also known as oncoprotein 18 (OP18), is a cytosolic phosphoprotein involved in regulating microtubule dynamics by promoting depolymerization or inhibiting polymerization of tubulin. It plays critical roles in cell cycle progression, mitosis, and intracellular signaling. Overexpression of Stathmin1 is associated with cancer proliferation, metastasis, and poor prognosis in various malignancies, including breast, ovarian, and prostate cancers. Its activity is tightly regulated by phosphorylation at specific serine residues (e.g., Ser16. Ser25. Ser38. and Ser63), which modulate its microtubule-destabilizing function.
The Stathmin1 (Ab-25) antibody is a monoclonal or polyclonal reagent designed to detect Stathmin1. often targeting a region containing phosphorylated or non-phosphorylated residues (e.g., around Ser25). This antibody is widely used in research to study Stathmin1 expression, post-translational modifications, and its role in diseases. Applications include Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Validated in specific cell lines or tissue samples, it helps elucidate Stathmin1's involvement in cancer progression, neuronal development, and neurodegenerative disorders. Researchers also utilize it to explore therapeutic strategies targeting microtubule regulation. Proper controls are essential to distinguish between phosphorylated and total Stathmin1 forms, depending on the antibody's design.
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