| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CTNNB1; CATNB; CTNB1; CTNNB; |
| Entrez GeneID | 1499; |
| WB Predicted band size | 92kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa. 35~39 (I-H-S-G-A) derived from Human b-Catenin. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于β-Catenin (Ser37)抗体的示例参考文献(注：文献为示例，实际引用需查阅具体数据库或厂商资料)：
---
1. **文献名称**：*"Wnt Signaling Regulation through β-Catenin Phosphorylation at Serine 37 in Colorectal Cancer"*
**作者**：Morin, P.J., et al.
**摘要**：研究利用β-Catenin (Ser37)特异性抗体(Ab-37)，通过免疫印迹和免疫荧光分析结直肠癌中Wnt信号通路的异常激活，揭示了Ser37磷酸化缺失与β-Catenin核积累的关系。
2. **文献名称**：*"GSK-3β-Mediated Phosphorylation of β-Catenin at Ser37: Implications for Protein Stability"*
**作者**：Liu, C., et al.
**摘要**：通过β-Catenin (Ser37)抗体验证GSK-3β对Ser37位点的磷酸化作用，证明该修饰是β-Catenin被蛋白酶体降解的关键步骤，并影响其在胚胎发育中的功能。
3. **文献名称**：*"Immunohistochemical Detection of Active β-Catenin Using Phospho-Specific Antibodies in Breast Cancer"*
**作者**：Kim, S.E., et al.
**摘要**：使用β-Catenin (Ser37)抗体对乳腺癌组织进行染色，发现低磷酸化水平与肿瘤侵袭性正相关，提示该抗体在临床预后评估中的潜在价值。
---
**建议**：如需真实文献，可通过以下途径查找：
- 在PubMed或Google Scholar搜索“beta-Catenin Ser37 antibody”或抗体货号(如CST #4176)。
- 访问抗体生产商官网(如Cell Signaling Technology)，查看产品页面的“References”栏目。
β-Catenin (Ab-37) antibody specifically targets the β-catenin protein phosphorylated at serine residue 37 (Ser37), a critical post-translational modification regulating its stability and function. β-Catenin plays dual roles: as a structural component of cell-cell adhesion complexes by interacting with cadherins, and as a key transcriptional co-activator in the Wnt signaling pathway. In unstimulated cells, cytoplasmic β-catenin is phosphorylated at Ser37 (and other residues) by the destruction complex (APC, Axin, GSK-3β, CK1), marking it for proteasomal degradation. Wnt signaling disrupts this complex, allowing β-catenin accumulation and nuclear translocation to drive target gene expression.
The Ab-37 antibody detects phosphorylated β-Catenin (Ser37), serving as a valuable tool to study Wnt pathway dynamics, particularly in contexts where β-catenin degradation is modulated. It is widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate cellular responses to Wnt ligands, tumorigenesis, and developmental processes. Dysregulation of β-catenin phosphorylation is implicated in cancers (e.g., colorectal, hepatocellular) and other diseases, making this antibody essential for exploring mechanisms of β-catenin stabilization, nuclear signaling, and its crosstalk with cell adhesion pathways. Its specificity helps distinguish active Wnt signaling states from cadherin-associated β-catenin pools.
×
