| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Proteasome subunit beta type-11, Proteasome subunit beta-5t, PSMB11 |
| Entrez GeneID | 122706 |
| WB Predicted band size | 32.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PSMB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human PSMB11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PSMB11抗体的假设性参考文献示例(仅供参考，实际文献需通过学术数据库查询)：
1. **文献名称**：《Immunoproteasome subunit PSMB11 regulates antigen presentation in dendritic cells》
**作者**：Smith A, et al.
**摘要**：本研究开发了高特异性PSMB11抗体，证实其在树突状细胞中的表达对MHC-I类抗原呈递至关重要，并揭示其调控机制。
2. **文献名称**：《A monoclonal antibody targeting PSMB11 inhibits tumor growth in murine models》
**作者**：Chen L, et al.
**摘要**：通过新型PSMB11单克隆抗体，作者发现抑制免疫蛋白酶体活性可增强肿瘤微环境中T细胞抗肿瘤反应，为癌症治疗提供潜在策略。
3. **文献名称**：《PSMB11 expression correlates with autoimmune disease progression》
**作者**：Tanaka K, et al.
**摘要**：利用多克隆PSMB11抗体检测患者样本，发现其表达水平与类风湿性关节炎疾病活动度正相关，提示其作为生物标志物的可能性。
4. **文献名称**：《Structural characterization of PSMB11 using cryo-EM and antibody-based mapping》
**作者**：Wong R, et al.
**摘要**：结合冷冻电镜和特异性抗体表位定位，解析了PSMB11在免疫蛋白酶体复合体中的构象变化及其底物结合关键区域。
**注**：以上为模拟数据，实际研究中建议通过PubMed、Web of Science等平台以“PSMB11 antibody”或“PSMB11 immunoproteasome”为关键词检索近期文献。
The PSMB11 antibody targets the proteasome subunit beta type-11 (PSMB11), a component of the immunoproteasome, a specialized form of the 20S proteasome. Unlike the constitutive proteasome, the immunoproteasome is predominantly expressed in immune cells and induced under inflammatory conditions by cytokines like IFN-γ. PSMB11. also known as β5i, replaces the β5 subunit in the immunoproteasome, altering protease activity to enhance production of antigenic peptides for major histocompatibility complex (MHC) class I presentation. This process is critical for adaptive immune responses, particularly in detecting infected or malignant cells.
PSMB11 antibodies are essential tools for studying immunoproteasome assembly, function, and regulation. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to quantify PSMB11 expression in various tissues or cell types. Research applications include investigating autoimmune diseases, cancer, and neurodegenerative disorders linked to dysregulated proteasome activity. For instance, elevated PSMB11 levels correlate with chronic inflammation, while its inhibition is explored in therapies targeting pathological immune activation.
Validating PSMB11 antibodies requires confirming specificity via knockout controls or siRNA knockdown. Cross-reactivity with constitutive β5 subunits (PSMB5/β5) must be ruled out. Understanding PSMB11’s role aids in developing immunomodulatory drugs or biomarkers for diseases with proteasome dysfunction.
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