Rabbit Polyclonal RET(C-termL1027) Antibody

The RET (C-term L1027) antibody is a specialized tool designed to detect the RET proto-oncogene protein, a receptor tyrosine kinase critical for cell signaling, development, and survival. RET is primarily associated with the regulation of neural crest and kidney development. Dysregulation of RET, through mutations or gene rearrangements, is implicated in multiple cancers, including medullary thyroid carcinoma (MTC), multiple endocrine neoplasia type 2 (MEN2), and non-small cell lung cancer (NSCLC). The C-terminal region of RET, particularly around residue L1027. is a hotspot for activating mutations (e.g., M918T in MEN2B) that drive constitutive kinase activity and oncogenesis. This antibody specifically targets the C-terminal domain near L1027. enabling the detection of both wild-type and mutant RET isoforms. It is widely used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to study RET expression, localization, and post-translational modifications in normal and pathological tissues. Its ability to recognize RET in its activated or dysregulated state makes it valuable for investigating RET-driven signaling pathways (e.g., MAPK, PI3K-AKT) and evaluating therapeutic agents targeting RET alterations. Validation of this antibody typically includes testing in RET-positive cell lines or tumor samples to confirm specificity and sensitivity.