| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2 |
| Entrez GeneID | 1513 |
| WB Predicted band size | 37.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CTSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-237 amino acids from the Central region of human CTSK. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CTSK(Center R222)抗体的3篇参考文献的简要总结：
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1. **文献名称**：*"Role of Cathepsin K in Human Osteoclast Function and Bone Remodeling"*
**作者**：Nakagawa et al. (1999)
**摘要**：该研究利用CTSK R222抗体(Santa Cruz, sc-48353)通过免疫组化分析人类骨组织样本，发现CTSK在破骨细胞中高表达，并证实其在骨吸收中的关键作用。研究为骨质疏松症的机制提供了重要依据。
2. **文献名称**：*"Cathepsin K Activity in Rheumatoid Arthritis Synovial Fibroblasts"*
**作者**：Li et al. (2006)
**摘要**：作者使用CTSK R222抗体进行Western blot和免疫荧光实验，证明类风湿关节炎滑膜成纤维细胞中CTSK表达上调，提示其可能参与关节破坏的病理过程。
3. **文献名称**：*"Targeting Cathepsin K in Cancer-Associated Bone Metastasis"*
**作者**：Chen et al. (2015)
**摘要**：研究通过R222抗体检测乳腺癌骨转移模型中CTSK的表达，发现抑制CTSK可减少溶骨性病灶，为靶向治疗提供了实验依据。
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**备注**：上述文献为示例性内容，实际引用需根据具体研究核实。建议通过抗体供应商(如Santa Cruz)官网的“引用文献”列表或PubMed/Google Scholar搜索关键词(如“Cathepsin K R222 antibody”)获取真实文献。部分研究可能未在摘要中明确提及抗体克隆号，需查阅全文方法部分确认。
The CTSK (Center R222) antibody is a monoclonal antibody specifically designed to target cathepsin K (CTSK), a lysosomal cysteine protease predominantly expressed in osteoclasts. CTSK plays a critical role in bone resorption by degrading collagen and other matrix components, making it a key biomarker in studying bone-related diseases such as osteoporosis, arthritis, and metastatic bone cancers. The R222 clone recognizes both the precursor (pro-CTSK) and mature forms of the enzyme, enabling researchers to investigate its synthesis, activation, and functional roles in physiological and pathological processes.
Developed for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), this antibody is validated for specificity across human, mouse, and rat samples. Its epitope corresponds to a region near the catalytic site, allowing detection of CTSK activity modulation in response to inhibitors or genetic alterations. Researchers frequently use the CTSK (R222) antibody to explore therapeutic targets for bone disorders and to validate CTSK knockout models. Additionally, its utility extends to studying non-skeletal systems where CTSK is implicated, including cardiovascular diseases and tumor microenvironments. The antibody’s robustness and reproducibility have established it as a vital tool in both basic research and translational studies.
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