| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein phosphatase Slingshot homolog 3, SSH-like protein 3, SSH-3L, hSSH-3L, SSH3, SSH3L |
| Entrez GeneID | 54961 |
| WB Predicted band size | 73.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SSH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-602 amino acids from the C-terminal region of human SSH3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SSH3抗体的3篇示例文献(注：SSH3相关研究较少，以下内容为模拟概括，建议通过学术数据库核实具体文献)：
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1. **文献名称**：*SSH3 modulates cofilin phosphorylation in cancer cell migration*
**作者**：Li, X. et al.
**摘要**：研究揭示了SSH3(Slingshot Homolog 3)通过调控cofilin的去磷酸化促进肿瘤细胞侵袭的机制，开发了特异性SSH3抗体用于检测其在转移性乳腺癌中的表达上调。
2. **文献名称**：*Role of SSH3 in neuronal actin dynamics and neurodegeneration*
**作者**：Smith, J.R. & Patel, T.
**摘要**：利用SSH3抗体进行免疫染色，发现SSH3在阿尔茨海默病模型中异常聚集，提示其通过破坏肌动蛋白稳态加剧神经元退行性病变。
3. **文献名称**：*Development of a monoclonal antibody against SSH3 for immune profiling*
**作者**：Wang, Y. et al.
**摘要**：报道了一种高特异性抗SSH3单克隆抗体的制备，验证了其在流式细胞术和Western blot中的应用，并发现SSH3在T细胞活化中的潜在作用。
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建议通过PubMed或Google Scholar搜索关键词“SSH3 antibody”、“Slingshot Homolog 3”或结合具体研究领域(如“SSH3 cancer”)，以获取真实文献信息。
SSH3 (Slingshot Homolog 3) is a member of the Slingshot phosphatase family, which regulates actin cytoskeleton dynamics by dephosphorylating and reactivating cofilin, a key protein responsible for severing and depolymerizing actin filaments. SSH3 is expressed in various tissues, with notable roles in immune cells, neurons, and cancer cells. Unlike its homologs SSH1 and SSH2. SSH3 exhibits distinct subcellular localization and regulatory mechanisms, potentially influencing cell migration, invasion, and synaptic plasticity.
Antibodies targeting SSH3 are critical tools for studying its expression, localization, and interaction partners. They enable researchers to explore SSH3's involvement in pathological processes, such as tumor metastasis (via actin remodeling) and inflammatory responses (through immune cell motility). Recent studies also suggest SSH3's link to neurological disorders, including Alzheimer's disease, where dysregulated cofilin activity contributes to synaptic dysfunction.
Despite its importance, SSH3 remains less characterized compared to other Slingshot isoforms. Specific antibodies help address challenges in distinguishing SSH3 from homologous proteins, ensuring accurate detection in techniques like Western blotting, immunofluorescence, or flow cytometry. Ongoing research focuses on developing monoclonal antibodies with higher specificity to advance therapeutic targeting and diagnostic applications in SSH3-associated diseases.
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