Rabbit Polyclonal DDX11 Antibody

The DDX11 antibody is a crucial tool for studying the DEAD-box helicase DDX11. a member of the DEAD-box protein family involved in nucleic acid metabolism. DDX11. also known as ChlR1. plays essential roles in DNA replication, repair, and sister chromatid cohesion, contributing to genome stability. It unwinds DNA-RNA hybrids and G-quadruplex structures, facilitating replication fork progression and resolving replication stress. Antibodies targeting DDX11 are widely used in molecular biology research to detect protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). These antibodies help elucidate DDX11's functional mechanisms in cellular processes and its association with diseases. Mutations in DDX11 are linked to Warsaw breakage syndrome, a rare genetic disorder characterized by microcephaly, growth retardation, and chromosomal instability. Additionally, DDX11 dysregulation has been implicated in cancer, as aberrant expression correlates with tumor progression and genomic instability. Validated DDX11 antibodies are critical for diagnostic and therapeutic research, particularly in understanding pathologies driven by replication errors or cohesion defects. Researchers rely on these reagents to explore DDX11's roles in development, disease, and potential as a biomarker or therapeutic target.