Rabbit Polyclonal ZNF813(N-term) Antibody

The ZNF813 (N-term) antibody is a targeted immunological reagent designed to detect the N-terminal region of the zinc finger protein 813 (ZNF813), encoded by the ZNF813 gene in humans. ZNF813 belongs to the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, a large group of transcription factors implicated in transcriptional regulation, chromatin remodeling, and epigenetic silencing. These proteins typically feature tandem C2H2-type zinc finger motifs for DNA binding and a KRAB domain that mediates protein-protein interactions, often recruiting co-repressor complexes to regulate gene expression. While the specific biological functions of ZNF813 remain under investigation, its structural homology suggests roles in developmental processes, cell differentiation, or tumorigenesis. The N-term antibody is commonly generated in rabbits or mice using synthetic peptides or recombinant protein fragments corresponding to the N-terminal region of ZNF813. It is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study ZNF813's expression patterns, subcellular localization, and interactions in various tissues or disease models. Validation typically includes knockout controls or siRNA-mediated knockdown to confirm specificity. Researchers employ this antibody to explore ZNF813's potential involvement in genetic disorders, cancer, or neurological conditions, though its full clinical relevance awaits further study.