Rabbit Polyclonal CCDC81 Antibody

The CCDC81 (Coiled-coil domain-containing protein 81) antibody is a tool used to detect and study the CCDC81 protein, which plays a role in cellular structure and function. CCDC81 is implicated in centriole and cilia-related processes, particularly in regulating cilia assembly and stability through interactions with microtubules and other cytoskeletal components. It is highly expressed in ciliated tissues, suggesting its importance in respiratory, reproductive, and sensory systems. Researchers employ CCDC81 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its localization, expression levels, and interactions in both normal and pathological contexts. Studies have linked CCDC81 dysfunction to ciliopathies—genetic disorders affecting cilia—such as respiratory defects, infertility, or retinal degeneration. The antibody's specificity is often validated using knockout cell lines or tissues to ensure accurate detection. Commercially available CCDC81 antibodies are typically raised in hosts like rabbits or mice, with formats including monoclonal or polyclonal options. Its applications extend to developmental biology, cancer research (due to cilia's role in cell signaling), and mechanistic studies of diseases involving ciliary dysregulation. Proper validation and optimization remain critical due to potential cross-reactivity with other coiled-coil domain proteins.