Rabbit Polyclonal RPS6KL1 Antibody

The RPS6KL1 antibody is a tool used to detect ribosomal protein S6 kinase-like 1 (RPS6KL1), a serine/threonine kinase belonging to the AGC family of kinases. RPS6KL1 shares structural homology with the p70 S6 kinase (S6K) family, particularly in its catalytic domain, but lacks the regulatory domains found in S6K proteins. It is encoded by the *RPS6KL1* gene, located on human chromosome 14q22.1. and is evolutionarily conserved across vertebrates. Functionally, RPS6KL1 has been implicated in cellular growth, proliferation, and survival pathways, potentially interacting with mTOR signaling. However, its precise biological roles remain less characterized compared to other S6K family members. Studies suggest its involvement in stress responses, neuronal development, and apoptosis regulation. The antibody is widely utilized in research to investigate RPS6KL1 expression, localization, and interaction partners via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It aids in exploring its potential links to diseases, including cancer and neurological disorders. Validation typically includes testing specificity through knockout controls or siRNA knockdown. Commercial RPS6KL1 antibodies are often raised against epitopes in the N-terminal or catalytic regions, with host species including rabbit or mouse. Proper validation ensures reliability in distinguishing RPS6KL1 from homologous kinases like S6K1/S6K2.