Rabbit Polyclonal CELA2A Antibody

The CELA2A antibody targets chymotrypsin-like elastase family member 2A (CELA2A), a serine protease primarily expressed in the pancreas. CELA2A, encoded by the *CELA2A* gene, is synthesized as a zymogen (protease precursor) and activated in the small intestine to participate in dietary protein digestion. It belongs to the elastase family, which hydrolyzes peptide bonds, particularly after hydrophobic residues. CELA2A is implicated in regulating pancreatic enzyme activity and may interact with protease inhibitors like SERPINB1. Research using CELA2A antibodies focuses on its role in pancreatic physiology, including proenzyme activation, and its potential dysregulation in diseases such as pancreatitis, pancreatic cancer, or digestive disorders. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to study protein expression, localization, and interactions. Recent studies suggest CELA2A may serve as a biomarker for pancreatic pathologies, as altered expression correlates with tumor progression or inflammation. However, its precise molecular mechanisms and extra-pancreatic functions remain under investigation. Commercial CELA2A antibodies are typically validated for specificity against recombinant or native proteins, aiding both basic research and clinical diagnostics.