| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2 |
| Entrez GeneID | 2826 |
| WB Predicted band size | 38.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CCR10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCR10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CCR10(N-term)抗体的3篇文献示例(内容为模拟概括，仅供参考)：
1. **"Characterization of a novel anti-CCR10 N-terminal antibody for detection of cutaneous lymphocyte trafficking"**
*作者：Smith A, et al.*
摘要：该研究开发了一种针对CCR10 N端表位的高特异性单克隆抗体，验证了其在人皮肤T细胞表面的表达，并证明其在银屑病模型中可用于监测淋巴细胞迁移。
2. **"CCR10 N-terminal domain antibodies inhibit chemotaxis in melanoma metastasis models"**
*作者：Zhang L, et al.*
摘要：通过靶向CCR10的N端结构域，研究者发现该抗体能够阻断CCL27介导的黑色素瘤细胞迁移，为抑制肿瘤转移提供了潜在治疗策略。
3. **"Structural mapping of CCR10 epitopes using N-terminal specific antibodies"**
*作者：Johnson R, et al.*
摘要：利用冷冻电镜技术解析了CCR10受体与其N端抗体的结合构象，揭示了抗体结合对受体构象变化的调控机制，为药物设计提供结构基础。
4. **"Dual role of CCR10 N-term antibody in atopic dermatitis: Diagnostic marker and therapeutic candidate"**
*作者：Tanaka K, et al.*
摘要：研究证实CCR10 N端抗体可同时作为特应性皮炎患者外周血免疫细胞的诊断标志物，并通过动物实验显示其阻断炎症细胞浸润的治疗潜力。
(注：以上为模拟文献，实际引用请通过PubMed/Web of Science等平台检索真实文献。)
The CCR10 (N-term) antibody is designed to target the N-terminal extracellular region of the chemokine receptor CCR10. a G protein-coupled receptor (GPCR) involved in immune cell trafficking and inflammatory responses. CCR10 binds primarily to the chemokine CCL27 (also known as CTACK) and CCL28. which regulate the migration of lymphocytes, particularly skin-homing T cells and mucosal immune cells. This receptor is expressed in tissues such as the skin, gut, and mucosal surfaces, playing roles in both homeostasis and disease, including inflammatory skin disorders (e.g., psoriasis, atopic dermatitis) and cancer metastasis.
The N-terminal domain of CCR10 is critical for ligand interaction and receptor activation. Antibodies targeting this region are often used to study receptor expression, localization, and function in experimental models. They are valuable tools in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect endogenous CCR10 in cells or tissue samples. Researchers also utilize CCR10 (N-term) antibodies to investigate its role in immune cell recruitment, epithelial barrier regulation, and tumor microenvironment interactions. Specificity for the N-terminus helps minimize cross-reactivity with other chemokine receptors, ensuring accurate detection. However, validation using knockout controls is essential to confirm antibody specificity in experimental settings.
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