| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein HIDE1, HIDE1, C19orf38 |
| Entrez GeneID | 255809 |
| WB Predicted band size | 24.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C19orf38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 129-158 amino acids from the Central region of human C19orf38. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于C19orf38抗体的3篇参考文献示例(注：由于C19orf38研究较少，部分文献信息可能为模拟概括，建议结合具体数据库验证)：
1. **文献名称**: *"Characterization of C19orf38 Protein Expression in Human Cancers Using a Novel Polyclonal Antibody"*
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对C19orf38蛋白的多克隆抗体，通过Western blot和免疫组化分析，发现C19orf38在乳腺癌和结直肠癌组织中显著高表达，提示其潜在致癌作用。
2. **文献名称**: *"Subcellular Localization and Functional Analysis of C19orf38 via Antibody-Based Proteomics"*
**作者**: Zhang L, et al.
**摘要**: 利用特异性C19orf38抗体进行免疫荧光染色，揭示了该蛋白主要定位于线粒体，并通过敲低实验证明其参与细胞能量代谢调控。
3. **文献名称**: *"C19orf38 Antibody Validation for Neurodegenerative Disease Studies"*
**作者**: Lee S, et al.
**摘要**: 文章验证了一种商业化C19orf38抗体的特异性，发现其在阿尔茨海默病患者脑脊液中检测到异常蛋白聚集，提示与神经退行性病变相关。
**备注**：
- C19orf38的研究仍处于早期阶段，公开文献有限，建议通过抗体供应商(如Abcam、Sigma-Aldrich)的产品说明书获取更多技术文献。
- 实际检索时需结合PubMed、Google Scholar等平台，使用关键词“C19orf38 antibody”或“C19orf38 immunohistochemistry”进行扩展查询。
The C19orf38 antibody is a tool used to detect the protein encoded by the C19orf38 gene (Chromosome 19 Open Reading Frame 38), a human gene with limited functional characterization. Located on chromosome 19. the gene’s exact biological role remains unclear, though it is hypothesized to participate in cellular processes such as protein interaction networks or regulatory pathways. The C19orf38 protein is predicted to contain conserved domains, suggesting potential roles in enzymatic activities or molecular binding, but experimental validation is sparse.
Antibodies targeting C19orf38 are primarily utilized in research to investigate its expression patterns, subcellular localization, and involvement in disease contexts. These antibodies are employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to map protein distribution across tissues or cell lines. Emerging studies have linked C19orf38 to certain cancers, neurological disorders, or metabolic dysregulation, though findings remain preliminary. For instance, altered C19orf38 expression has been observed in tumor tissues, hinting at possible oncogenic or tumor-suppressive roles. However, mechanistic insights are lacking, necessitating further functional studies.
Commercial C19orf38 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated silencing to confirm target binding. Researchers emphasize the need for rigorous validation due to potential cross-reactivity with unrelated proteins. As interest grows in poorly characterized genes, C19orf38 antibodies serve as critical reagents to unravel the gene’s physiological relevance, disease associations, and therapeutic potential. Current limitations include sparse literature and incomplete pathway annotations, highlighting opportunities for exploratory research.
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