Rabbit Polyclonal MGAT4A(N-Term) Antibody

The MGAT4A (N-Term) antibody is designed to target the N-terminal region of the MGAT4A enzyme (mannosyl (α-1.3-)-glycoprotein β-1.4-N-acetylglucosaminyltransferase), a key glycosyltransferase involved in N-glycan biosynthesis. MGAT4A catalyzes the addition of N-acetylglucosamine (GlcNAc) to the α-1.3-mannose branch of core structures during the formation of complex-type glycans, influencing cell-surface protein interactions, immune responses, and cellular signaling. This antibody is commonly used in research to study MGAT4A expression, localization, and function in physiological and pathological contexts, such as cancer, inflammation, and metabolic disorders. By binding specifically to the N-terminal epitope, it enables detection of MGAT4A in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing this antibody have linked altered MGAT4A activity to diseases like hepatocellular carcinoma and diabetes, where abnormal glycosylation patterns affect cell adhesion, metastasis, or insulin sensitivity. Its role in modulating glycan structures also makes it relevant in immunological research, particularly in understanding T-cell receptor signaling and pathogen-host interactions. The MGAT4A (N-Term) antibody serves as a critical tool for dissecting the enzyme's contribution to glycosylation-dependent cellular mechanisms and disease progression.