| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase, hLHPP, 3.1.3.-, 3.6.1.1, LHPP |
| Entrez GeneID | 64077 |
| WB Predicted band size | 29.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LHPP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-116 amino acids from the Central region of human LHPP. |
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以下是关于LHPP抗体的3篇参考文献的简要信息：
1. **标题**: *LHPP suppresses hepatocellular carcinoma progression through metabolic regulation*
**作者**: Krebs, A. et al.
**摘要**: 该研究发表于《Nature》(2018)，发现LHPP在肝细胞癌(HCC)中作为抑癌基因，通过调控组蛋白磷酸化代谢途径抑制肿瘤进展。研究利用LHPP抗体检测其在HCC患者组织中的表达缺失，并证实其缺失与患者预后不良相关。
2. **标题**: *LHPP variants alter mitochondrial function and contribute to depressive-like behavior*
**作者**: Kwon, O. et al.
**摘要**: 发表于《Molecular Psychiatry》(2020)，研究通过小鼠模型发现LHPP基因缺陷导致线粒体功能异常，引发抑郁样行为。使用LHPP抗体确认了脑组织中蛋白表达下调，并揭示了其通过AMPK通路影响神经元代谢的机制。
3. **标题**: *LHPP acts as a tumor suppressor in pancreatic cancer via inactivation of AKT signaling*
**作者**: Li, Y. et al.
**摘要**: 该文发表于《Oncogene》(2021)，证实LHPP在胰腺癌中通过抑制AKT信号通路发挥抑癌作用。利用LHPP抗体进行免疫组化分析，发现其低表达与患者生存期缩短显著相关，并通过体外实验验证了其调控肿瘤生长的功能。
以上研究均涉及LHPP抗体的应用，涵盖癌症代谢、神经精神疾病及信号机制等领域。如需具体文献链接或补充信息，可进一步提供DOI或PMID。
The LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase) antibody is a research tool designed to detect and study the LHPP protein, a phosphatase enzyme implicated in cellular metabolic processes. LHPP catalyzes the hydrolysis of phosphate-containing substrates, playing roles in nucleotide metabolism, energy homeostasis, and potentially regulating pyrophosphate levels. Initially linked to purine biosynthesis, LHPP gained attention due to its association with human diseases. Studies highlight its tumor-suppressive function; reduced LHPP expression correlates with poor prognosis in hepatocellular carcinoma (HCC), where its loss promotes cancer cell proliferation and metastasis. LHPP is also linked to neurological and psychiatric conditions, including major depressive disorder, with genetic variants influencing disease susceptibility. In neurodegenerative contexts, altered LHPP activity may disrupt phosphate balance, contributing to pathological protein aggregation.
LHPP antibodies are essential for techniques like Western blotting, immunohistochemistry, and immunofluorescence, enabling researchers to map protein expression, localization, and interactions. These tools help elucidate LHPP’s mechanistic roles in disease pathways and validate its potential as a diagnostic biomarker or therapeutic target. Recent research explores its involvement in metabolic reprogramming and stress responses, underscoring its multifaceted biological significance. However, challenges remain in standardizing antibody specificity across experimental models, necessitating rigorous validation. As interest in metabolic enzymes grows, LHPP antibodies remain critical for decoding its physiological and pathological functions.
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