| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 40S ribosomal protein S17, RPS17 |
| Entrez GeneID | 6218 |
| WB Predicted band size | 15.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This RPS17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 55-87 amino acids from the Central region of human RPS17. |
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以下是关于RPS17抗体的3篇文献的模拟示例(注：以下内容为虚构示例，实际文献需通过学术数据库检索验证)：
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1. **文献名称**: *RPS17 Antibody Validation in Hematopoietic Disorders*
**作者**: Smith A et al.
**摘要**: 本研究验证了RPS17抗体在骨髓异常增生综合征(MDS)患者样本中的特异性，发现RPS17蛋白表达水平与5q染色体缺失相关，提示其作为潜在诊断标志物的可能性。
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2. **文献名称**: *Structural Localization of RPS17 in Ribosome Assembly*
**作者**: Chen L et al.
**摘要**: 通过免疫荧光和Western blot分析，揭示了RPS17在核糖体小亚基组装中的关键作用，并利用特异性抗体确认了其在核仁中的动态定位。
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3. **文献名称**: *RPS17 Overexpression in Breast Cancer Progression*
**作者**: Gupta R et al.
**摘要**: 研究发现RPS17在乳腺癌组织中高表达，其抗体检测显示与肿瘤增殖和转移相关，可能成为治疗靶点。
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**提示**：真实文献可通过PubMed或Google Scholar搜索关键词(如“RPS17 antibody”、“RPS17 function”)获取，建议结合具体研究需求筛选。
The RPS17 antibody is a research tool designed to detect and study ribosomal protein S17 (RPS17), a component of the 40S ribosomal subunit involved in protein synthesis. Encoded by the RPS17 gene, this protein plays a dual role: it contributes to ribosome assembly and mRNA translation, while also participating in non-ribosomal functions like cell cycle regulation and apoptosis. Dysregulation of RPS17 has been linked to cancers, including leukemia and solid tumors, where its overexpression may drive proliferation or metastasis. Additionally, RPS17 mutations are associated with Diamond-Blackfan anemia (DBA), a rare genetic disorder characterized by red blood cell deficiency.
Antibodies targeting RPS17 enable researchers to investigate its expression patterns, subcellular localization, and interactions via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These tools are critical for understanding RPS17's role in ribosomopathies and oncogenesis, as well as evaluating its potential as a diagnostic biomarker or therapeutic target. Validated antibodies often undergo specificity checks using knockout cell lines or siRNA-mediated knockdown to ensure accurate detection. Given RPS17's emerging significance in both basic ribosome biology and disease mechanisms, these antibodies support advancements in molecular diagnostics and targeted therapy development.
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