| WB | 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dual specificity testis-specific protein kinase 2, Testicular protein kinase 2, TESK2 |
| Entrez GeneID | 10420 |
| WB Predicted band size | 63.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TESK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the Central region of human TESK2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TESK2抗体的3篇参考文献示例(注：部分内容为示例性概括，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *"TESK2 regulates actin cytoskeletal reorganization via LIMK/cofilin pathway in cancer cell migration"*
**作者**: Yamamoto H, et al.
**摘要**: 本研究利用TESK2特异性抗体(克隆号C225)探究TESK2在癌细胞迁移中的作用，发现其通过磷酸化cofilin调控肌动蛋白重组，促进肿瘤侵袭。
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2. **文献名称**: *"Characterization of TESK2 antibody for detecting phosphorylation-dependent signaling in TGF-β pathways"*
**作者**: Smith J, et al.
**摘要**: 文章验证了TESK2抗体(Center C225)在Western blot和免疫荧光中的特异性，证明TESK2参与TGF-β诱导的上皮-间质转化(EMT)过程。
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3. **文献名称**: *"Dual roles of TESK2 in neuronal development and synaptic plasticity"*
**作者**: Chen L, et al.
**摘要**: 通过C225抗体检测发现，TESK2在小鼠海马神经元中高表达，调控突触可塑性，并影响学习记忆功能，提示其与神经退行性疾病潜在关联。
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**备注**：以上文献信息为示例，实际引用需通过PubMed、Google Scholar等平台以“TESK2 antibody”“C225 clone”等关键词检索确认。部分商业抗体厂商(如Cell Signaling Technology)的技术文档也可能提供相关应用数据。
The TESK2 (Center C225) antibody is a research tool designed to target the Testis-Specific Kinase 2 (TESK2), a serine/threonine kinase encoded by the TESK2 gene located on human chromosome 1p32.3. TESK2 belongs to the TESK kinase family, alongside TESK1. and shares structural homology with LIM domain-containing kinases. It plays a regulatory role in cytoskeletal dynamics, particularly through phosphorylation of cofilin, an actin-binding protein. This activity modulates actin filament reorganization, impacting cell motility, adhesion, and morphological changes. TESK2 is predominantly expressed in testicular germ cells, suggesting a potential role in spermatogenesis, though its broader physiological functions remain under investigation.
The Center C225 antibody is a polyclonal antibody raised against a synthetic peptide corresponding to a central region of the human TESK2 protein. It is commonly used in techniques like Western blotting (WB) and immunohistochemistry (IHC) to detect TESK2 expression in tissue samples or cell lysates. Researchers utilize this antibody to explore TESK2's involvement in cellular processes such as mitosis, apoptosis, and cancer progression, where aberrant cytoskeletal regulation is implicated. Validation studies typically confirm its specificity via knockout/knockdown controls. While TESK2's exact pathological roles are not fully defined, this antibody remains a critical reagent for elucidating its biological significance in normal and diseased states.
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