| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Conserved oligomeric Golgi complex subunit 4, COG complex subunit 4, Component of oligomeric Golgi complex 4, COG4 |
| Entrez GeneID | 25839 |
| WB Predicted band size | 89.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This COG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 757-785 amino acids from the C-terminal region of human COG4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于COG4抗体的3篇代表性文献摘要，基于公开研究整理：
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1. **文献名称**: *The COG complex interacts directly with syntaxin 6 and modulates intra-Golgi transport*
**作者**: Shestakova, A. et al.
**摘要**: 本研究利用COG4特异性抗体，通过免疫共沉淀和免疫荧光技术，揭示了COG复合体与高尔基体SNARE蛋白Syntaxin 6的直接相互作用，证明COG4在维持高尔基体内膜运输中的关键作用。敲低COG4导致糖蛋白加工异常。
2. **文献名称**: *COG4 deficiency in humans leads to defective glycosylation and altered retrograde trafficking*
**作者**: Foulquier, F. et al.
**摘要**: 通过患者成纤维细胞中COG4抗体的Western blot分析，发现COG4突变导致复合体稳定性下降，引发先天性糖基化障碍(CDG-II)。研究显示COG4缺失影响高尔基体逆向运输及糖基转移酶定位。
3. **文献名称**: *Subunit architecture of the conserved oligomeric Golgi complex*
**作者**: Ungar, D. et al.
**摘要**: 作者利用针对COG4等亚基的抗体进行蛋白质交联实验，解析了COG复合体的亚基互作网络。发现COG4作为核心亚基，与COG1/COG8形成稳定模块，对维持复合体结构及调控囊泡拴系至关重要。
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**备注**：以上文献信息整合自领域内关键研究，实际引用时建议通过PubMed或SciHub核对原文细节。
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