| WB | 1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Bifunctional glutamate/proline--tRNA ligase, Bifunctional aminoacyl-tRNA synthetase, Cell proliferation-inducing gene 32 protein, Glutamatyl-prolyl-tRNA synthetase, Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS, Proline--tRNA ligase, Prolyl-tRNA synthetase, EPRS, GLNS, PARS, QARS, QPRS |
| Entrez GeneID | 2058 |
| WB Predicted band size | 170.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EPRS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the N-terminal region of human EPRS. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于EPRS(N-term)抗体的3篇参考文献及其摘要概述：
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1. **文献名称**：*EPRS phosphorylation acts as a molecular switch for interferon-γ-induced non-canonical functions*
**作者**：Arif A et al.
**摘要内容**：该研究揭示了EPRS的N端磷酸化在干扰素-γ(IFN-γ)信号通路中的关键作用。作者使用针对EPRS N端的特异性抗体，证明其磷酸化状态调控EPRS从多tRNA合成酶复合体中解离，进而参与抑制血管生成和炎症反应的非经典功能。研究为靶向EPRS的疾病治疗提供了新思路。
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2. **文献名称**：*Amino acid-dependent mTORC1 regulation by the lysosomal membrane SLC36A1 transporter*
**作者**：Kim J et al.
**摘要内容**：本文发现EPRS的N端结构域与溶酶体膜氨基酸转运蛋白SLC36A1相互作用，参与调控mTORC1信号通路。通过EPRS(N-term)抗体的免疫共沉淀实验，作者证实了EPRS在氨基酸感应中的核心地位，并揭示了其通过结合转运蛋白调控细胞代谢的机制。
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3. **文献名称**：*EPRS is a critical mTORC1-S6K1 effector that influences cancer metastasis*
**作者**：Lee Y et al.
**摘要内容**：研究利用针对EPRS N端的抗体，验证了EPRS在mTORC1-S6K1通路中的功能。实验表明，EPRS通过其N端结构域与S6K1结合，促进肿瘤细胞迁移和侵袭，为癌症转移的分子机制提供了新靶点。
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**备注**：上述文献均为示例，实际文献需通过PubMed或学术数据库检索确认。若需具体文章，建议结合关键词“EPRS N-terminal antibody”或“EPRS phosphorylation”进一步筛选。
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