Rabbit Polyclonal CAPZA1(N-term) Antibody

The CAPZA1 (N-term) antibody targets the N-terminal region of Capping Protein Alpha 1 (CAPZA1), a key component of the heterodimeric F-actin capping protein complex (CAPZA1/CAPZB). This complex regulates actin filament dynamics by binding to the fast-growing (barbed) ends of actin filaments, stabilizing them and controlling their elongation. CAPZA1 plays a critical role in cell motility, cytokinesis, and cytoskeletal organization by modulating actin polymerization-depolymerization cycles. The antibody is commonly used in research to study CAPZA1 expression, localization, and function in cellular processes, employing techniques like Western blotting, immunofluorescence, and immunoprecipitation. Its specificity for the N-terminal region helps distinguish CAPZA1 from other isoforms or homologous proteins, ensuring accurate detection. CAPZA1 dysregulation has been implicated in neurological disorders, cancer metastasis, and developmental defects, making this antibody a valuable tool for exploring disease mechanisms. Validation typically includes testing in knockout cell lines or tissues to confirm specificity. Researchers also use it to investigate interactions between CAPZA1 and binding partners, such as CAPZB or signaling molecules involved in cytoskeletal remodeling.