| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein kinase STYK1, Novel oncogene with kinase domain, Protein PK-unique, Serine/threonine/tyrosine kinase 1, STYK1, NOK |
| Entrez GeneID | 55359 |
| WB Predicted band size | 47.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This STYK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-64 amino acids from the N-terminal region of human STYK1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STYK1 (N-term)抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
1. **文献名称**：*STYK1 promotes tumor growth and metastasis by reducing immunogenicity in head and neck squamous cell carcinoma*
**作者**：Li Y, et al.
**摘要**：研究利用STYK1 (N-term)抗体通过Western blot和免疫组化验证STYK1在头颈鳞癌中的高表达，发现其通过调控PD-L1表达抑制T细胞活性，促进肿瘤免疫逃逸。
2. **文献名称**：*STYK1 regulates ovarian cancer progression via ERK/MAPK signaling pathway*
**作者**：Wang H, et al.
**摘要**：该研究使用STYK1 (N-term)抗体进行免疫荧光和流式细胞术，证实STYK1通过激活ERK/MAPK通路促进卵巢癌细胞增殖和侵袭，并与患者预后不良相关。
3. **文献名称**：*The role of STYK1 in colorectal cancer stemness and chemoresistance*
**作者**：Zhang Q, et al.
**摘要**：通过STYK1 (N-term)抗体的免疫沉淀实验，研究发现STYK1与β-catenin相互作用增强Wnt信号通路，促进结直肠癌干性特征及化疗耐药。
(注：以上为模拟文献案例，实际文献需通过PubMed或学术数据库检索确认。)
**Background of STYK1 (N-term) Antibody**
The STYK1 (Serine/Threonine/Tyrosine Kinase 1) protein, also known as NKF3 or OK/SW-cl.23. is a member of the tyrosine kinase-like subfamily. It contains a conserved kinase domain but lacks extracellular and transmembrane regions, suggesting atypical signaling roles. STYK1 is implicated in regulating cell proliferation, apoptosis, and tumorigenesis, with studies linking its overexpression to cancers such as breast, lung, and hepatocellular carcinoma.
The STYK1 (N-term) antibody is a polyclonal or monoclonal reagent specifically targeting the N-terminal region of the human STYK1 protein. This region is critical for its kinase activity and interactions with downstream signaling pathways, including MAPK and PI3K/AKT. The antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect STYK1 expression levels and localization in cells or tissues.
Research utilizing this antibody has helped elucidate STYK1’s role in promoting tumor growth, metastasis, and therapy resistance, making it a potential biomarker or therapeutic target. Its specificity for the N-terminal domain ensures minimal cross-reactivity with other kinases, enhancing experimental reliability. Validated in multiple species, including human and mouse, the antibody supports both basic and translational studies in oncology and molecular biology.
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