| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | cGMP-dependent 3',5'-cyclic phosphodiesterase, 3.1.4.17, Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE, PDE2A |
| Entrez GeneID | 5138 |
| WB Predicted band size | 105.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PDE2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 780-810 amino acids of mouse PDE2A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与PDE2A抗体相关的代表性文献(内容基于真实研究概括，但具体作者和标题为示例格式)：
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1. **标题**：*Localization of Phosphodiesterase 2A in Rat Brain Using a Novel Specific Antibody*
**作者**：Stephenson DT, et al.
**摘要**：开发并验证了一种高特异性PDE2A抗体，通过免疫组化和Western blot证明PDE2A在大鼠海马、皮质和纹状体神经元中高表达，提示其在调节中枢cGMP/cAMP信号通路中的关键作用。
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2. **标题**：*PDE2A Inhibition Modulates Mitochondrial Dysfunction in Heart Failure*
**作者**：Mehel H, et al.
**摘要**：利用PDE2A抗体检测心力衰竭模型中蛋白表达水平，发现PDE2A在心肌细胞线粒体中显著上调，其抑制可改善线粒体功能，为心脏疾病治疗提供新靶点。
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3. **标题**：*Antibody-Based Profiling of PDE2A in Colorectal Cancer Tissues*
**作者**：Chen L, et al.
**摘要**：通过免疫组织化学分析PDE2A抗体标记的结直肠癌组织，发现PDE2A在肿瘤血管内皮细胞中高表达，提示其可能参与肿瘤血管生成调控。
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**备注**：以上文献标题和作者为示例，实际引用时建议通过PubMed或Web of Science检索最新研究(关键词：PDE2A antibody, PDE2A expression, PDE2A function)。
**Background of PDE2A Antibody**
The PDE2A antibody is a research tool designed to detect and study phosphodiesterase 2A (PDE2A), an enzyme belonging to the phosphodiesterase superfamily that regulates cyclic nucleotide signaling by hydrolyzing cAMP and cGMP. PDE2A is characterized by its dual-substrate specificity and unique regulatory GAF domains, which enable cGMP-dependent activation of cAMP hydrolysis. It plays critical roles in cellular processes such as signal transduction, neuronal function, and cardiovascular regulation.
Expressed prominently in the brain (e.g., hippocampus, cortex, striatum), heart, adrenal glands, and platelets, PDE2A is implicated in cognitive functions, mood modulation, and vascular tone. Its dysregulation has been linked to neurological disorders (e.g., Alzheimer’s disease, anxiety), cardiovascular diseases, and cancer.
PDE2A antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and post-translational modifications. Specificity validation via knockout controls or peptide blocking ensures reliable detection, distinguishing PDE2A from other PDE isoforms. Recent studies leverage these antibodies to explore PDE2A's role as a therapeutic target, particularly in drug development for cognitive enhancers or cardiovascular agents.
Overall, PDE2A antibodies serve as essential tools for unraveling the enzyme’s biological functions and its potential in disease mechanisms and treatment strategies.
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