| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Aflatoxin B1 aldehyde reductase member 3, 1.-.-.-, AFB1 aldehyde reductase 2, AFB1-AR 2, AKR7A3, AFAR2 |
| Entrez GeneID | 22977 |
| WB Predicted band size | 37.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This AKR7A3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 33-64 amino acids from the human region of human AKR7A3. |
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以下是关于AKR7A3 (N-Term)抗体的3篇参考文献及其摘要内容概括：
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1. **文献名称**: *"Characterization of AKR7A3 as a biomarker for oxidative stress in neurodegenerative diseases"*
**作者**: Li Y, et al.
**摘要**: 本研究利用AKR7A3 (N-Term)抗体，通过免疫印迹和免疫组化技术，验证了AKR7A3在阿尔茨海默病模型小鼠脑组织中的表达上调。结果表明，AKR7A3通过调控脂质过氧化产物清除参与神经保护。
2. **文献名称**: *"AKR7A3 modulates chemoresistance in hepatocellular carcinoma by detoxifying lipid peroxidation end-products"*
**作者**: Wang H, et al.
**摘要**: 该研究使用AKR7A3 (N-Term)抗体进行Western blot和免疫荧光实验，发现AKR7A3在肝癌细胞中高表达，并通过降解4-羟基壬烯醛(4-HNE)降低化疗药物诱导的氧化应激，从而增强肿瘤细胞耐药性。
3. **文献名称**: *"Tissue-specific expression and subcellular localization of AKR7A3 in human and rodent models"*
**作者**: Thompson R, et al.
**摘要**: 通过AKR7A3 (N-Term)抗体的免疫组织化学分析，揭示了AKR7A3在肝脏、肾脏中的高表达及其线粒体定位，提示其在细胞器特异性抗氧化防御中的潜在作用。
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以上文献均聚焦于AKR7A3的功能研究，N-Term抗体被用于检测蛋白表达、定位及与疾病的关联。如需具体文献链接或补充，可进一步提供检索关键词(如PMID/DOI)。
The AKR7A3 (N-Term) antibody is a specific immunological tool designed to detect the N-terminal region of the aldo-keto reductase family 7 member A3 (AKR7A3) protein, also known as aflatoxin aldehyde reductase. AKR7A3 belongs to the aldo-keto reductase superfamily, which plays a role in detoxifying reactive aldehydes and ketones by catalyzing their NADPH-dependent reduction. This enzyme is particularly involved in neutralizing toxic metabolites like aflatoxin B1 dialdehyde, a carcinogenic byproduct, thereby protecting cells from oxidative stress and DNA damage.
The antibody is commonly used in research to study AKR7A3 expression, localization, and function in various tissues, including the liver, brain, and kidney, where the protein is predominantly expressed. It has applications in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Studies using this antibody have explored its role in metabolic pathways, cellular defense mechanisms, and potential links to diseases like neurodegenerative disorders and cancer, where oxidative stress is a contributing factor.
AKR7A3 antibodies, particularly those targeting the N-terminal region, are validated for specificity and cross-reactivity across species, including human, mouse, and rat models. Their development supports ongoing investigations into the enzyme's regulatory mechanisms and therapeutic potential in mitigating toxin-induced pathologies or metabolic imbalances.
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