| WB | 1/4000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Proline dehydrogenase 1, mitochondrial, 1.5.5.2, Proline oxidase, Proline oxidase 2, p53-induced gene 6 protein, PRODH, PIG6, POX2 |
| Entrez GeneID | 5625 |
| WB Predicted band size | 68.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PRODH antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 429-461 amino acids from human PRODH. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PRODH抗体的3篇参考文献示例(注：内容为示例性概括，实际文献需通过学术数据库查询)：
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1. **文献名称**: "Proline dehydrogenase (PRODH) polymorphisms and schizophrenia susceptibility"
**作者**: Kamiya A., et al.
**摘要**: 研究利用PRODH特异性抗体检测了精神分裂症患者脑组织中PRODH的蛋白表达水平，发现特定基因突变导致PRODH表达下调，可能通过影响脯氨酸代谢参与神经发育异常。
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2. **文献名称**: "PRODH expression in colorectal cancer: A novel prognostic biomarker"
**作者**: Smith J.L., et al.
**摘要**: 通过免疫组化与Western blot分析，发现PRODH在结直肠癌组织中高表达，且与患者生存率负相关，提示其可能作为肿瘤代谢重编程的潜在标志物。
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3. **文献名称**: "Optimization of PRODH antibody for mitochondrial protein detection"
**作者**: Chen R., et al.
**摘要**: 文章验证了多种PRODH抗体的特异性，优化了其在细胞线粒体分离样本中的免疫印迹条件，为脯氨酸代谢通路研究提供了方法学支持。
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**建议**：可通过PubMed或Google Scholar搜索关键词“PRODH antibody”、“PRODH immunohistochemistry”等获取真实文献。部分研究可能聚焦于PRODH在代谢疾病或癌症中的功能机制及抗体应用。
The PRODH antibody is a crucial tool for studying proline dehydrogenase (PRODH), a mitochondrial enzyme encoded by the PRODH gene located on chromosome 22q11.2. PRODH catalyzes the first step in proline catabolism, converting proline to Δ1-pyrroline-5-carboxylate (P5C), a process linked to cellular energy production, redox balance, and apoptosis. This enzyme is highly expressed in the brain, kidney, and liver, and its dysfunction has been implicated in several disorders. Notably, PRODH gene deletions or mutations are associated with 22q11.2 deletion syndrome, which increases susceptibility to schizophrenia, autism, and other neuropsychiatric conditions. Additionally, PRODH plays dual roles in cancer—acting as a tumor suppressor by modulating apoptosis via p53-dependent pathways or promoting tumor survival under metabolic stress.
The PRODH antibody enables researchers to detect and quantify PRODH protein levels in tissues or cultured cells using techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is essential for investigating PRODH's tissue-specific expression, subcellular localization, and interactions with signaling pathways. Studies utilizing this antibody have shed light on PRODH's role in metabolic reprogramming, oxidative stress responses, and its potential as a biomarker or therapeutic target in diseases like cancer and neurological disorders. Its specificity and reliability make it a cornerstone in both basic research and translational studies exploring proline metabolism dysregulation.
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