Rabbit Polyclonal MYBPC3(N-term) Antibody

The MYBPC3 (N-term) antibody is a crucial tool for studying cardiac myosin-binding protein C (cMyBP-C), a sarcomeric protein encoded by the MYBPC3 gene, predominantly expressed in cardiac muscle. cMyBP-C plays a vital role in regulating myocardial contraction and maintaining sarcomere structure through interactions with myosin and titin. The N-terminal domain is particularly important for modulating cross-bridge cycling and calcium sensitivity. Mutations in MYBPC3 are linked to hypertrophic cardiomyopathy (HCM), a leading cause of sudden cardiac death, often due to haploinsufficiency or truncated protein production. The MYBPC3 (N-term) antibody specifically targets epitopes near the N-terminus, enabling detection of full-length cMyBP-C and potential disease-associated truncated isoforms. It is widely used in Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and post-translational modifications in cardiac tissues or cultured cardiomyocytes. Researchers employ this antibody to investigate pathogenic mechanisms in HCM, study genotype-phenotype correlations, and evaluate therapeutic interventions aiming to restore cMyBP-C function. Its specificity for the N-terminal region makes it valuable for distinguishing normal from mutant proteins in both basic research and potential diagnostic applications.