| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Immunoglobulin superfamily member 8, IgSF8, CD81 partner 3, Glu-Trp-Ile EWI motif-containing protein 2, EWI-2, Keratinocytes-associated transmembrane protein 4, KCT-4, LIR-D1, Prostaglandin regulatory-like protein, PGRL, CD316, IGSF8, CD81P3, EWI2, KCT4 |
| Entrez GeneID | 93185 |
| WB Predicted band size | 65.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This IGSF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 amino acids from the Central region of human IGSF8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IGSF8抗体的模拟参考文献示例(文献为虚构，仅供参考格式)：
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1. **文献名称**: *IGSF8 modulates immune checkpoint expression in hepatocellular carcinoma*
**作者**: Chen L, Wang X, et al. (2021)
**摘要**: 研究通过免疫组化(使用抗IGSF8抗体)发现IGSF8在肝癌细胞中高表达，并通过PD-L1调控促进免疫逃逸，提示其作为潜在治疗靶点。
2. **文献名称**: *Development of a high-affinity monoclonal antibody against IGSF8 for diagnostic applications*
**作者**: Kim S, Ito M, et al. (2019)
**摘要**: 报道了一种新型抗IGSF8单克隆抗体的开发，验证其在ELISA和流式细胞术中的特异性，并成功应用于胃癌患者的组织样本检测。
3. **文献名称**: *IGSF8 regulates synaptic adhesion and neuronal connectivity in the developing brain*
**作者**: Rodriguez P, Müller U, et al. (2020)
**摘要**: 利用IGSF8抗体进行免疫荧光染色，发现其在小鼠脑发育中调控突触黏附分子互作，影响神经元网络形成。
4. **文献名称**: *IGSF8 as a biomarker for tumor-associated macrophage infiltration in breast cancer*
**作者**: Gupta R, Patel K, et al. (2022)
**摘要**: 通过Western blot(使用IGSF8抗体)和单细胞测序，揭示IGSF8表达与乳腺癌中巨噬细胞浸润相关，影响患者预后。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“IGSF8 antibody”或“IGSF8 function”获取最新研究。部分研究可能涉及IGSF8抗体在疾病机制或诊断中的应用。
The immunoglobulin superfamily member 8 (IGSF8), also known as PGRL or CD316. is a transmembrane protein characterized by extracellular immunoglobulin-like domains and intracellular signaling motifs. It plays roles in cell adhesion, immune regulation, and synaptic signaling, with emerging links to cancer and neurological disorders. IGSF8 antibodies are specialized tools designed to detect and study this protein’s expression, localization, and function.
These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore IGSF8’s involvement in physiological and pathological processes. Research highlights its interaction with proteins like JAML and connexins, suggesting roles in immune cell communication and tissue homeostasis. In cancer, IGSF8 may influence tumor microenvironment interactions or metastasis, though mechanisms remain under investigation.
Commercially available IGSF8 antibodies are typically validated for specificity against human or murine isoforms, targeting specific epitopes within its extracellular or intracellular regions. Challenges include cross-reactivity with related immunoglobulin superfamily proteins, necessitating careful validation. Current studies leverage these antibodies to dissect IGSF8’s signaling pathways, offering insights into therapeutic targeting for diseases like glioblastoma or autoimmune conditions. Ongoing work aims to clarify its dual roles in immune regulation and neural connectivity.
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