Rabbit Polyclonal DLEU7(N-Term) Antibody

The DLEU7 (N-Term) antibody targets the N-terminal region of the Deleted in Leukemia 7 (DLEU7) protein, encoded by the DLEU7 gene located on chromosome 13q14.3. This genomic region is frequently deleted in chronic lymphocytic leukemia (CLL) and other B-cell malignancies, suggesting a potential tumor suppressor role. DLEU7 is part of a larger gene cluster that includes the tumor suppressor microRNAs miR-15a and miR-16-1. which regulate apoptosis and cell cycle progression. While DLEU7's exact function remains under investigation, studies suggest it may participate in immune regulation, epigenetic modification, and cancer pathogenesis. The protein is expressed in lymphoid tissues and shows altered expression patterns in hematologic cancers. The DLEU7 (N-Term) antibody is widely used in research to study protein localization, expression levels, and molecular interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal epitope helps distinguish DLEU7 from other proteins in the 13q14 region, aiding investigations into its role in tumor suppression, B-cell development, and disease mechanisms. Recent studies also explore its potential involvement in autoimmune disorders and viral responses, expanding its relevance beyond oncology.