| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Putative segment polarity protein dishevelled homolog DVL1P1, DSH homolog 1-like, Segment polarity protein dishevelled homolog DVL-1-like, Dishevelled-1-like, DVL1P1, DVL, DVL1, DVL1L1 |
| WB Predicted band size | 73.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DVL1L1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 39-71 amino acids from human DVL1L1. |
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以下是关于DVL1(可能涉及N端抗体使用)的参考文献示例，基于真实研究领域整理(注：文献标题和作者为示例性描述，具体文献需通过学术数据库验证)：
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1. **"Differential roles of Dishevelled-1 and Dishevelled-2 in Wnt signaling and mammalian development"**
*作者：Wang et al., 2016*
**摘要**：研究DVL1和DVL2在Wnt/β-catenin信号通路中的功能差异，通过N端特异性抗体验证两者在胚胎发育中的亚细胞定位及表达水平。
2. **"Monoclonal antibody targeting the N-terminal domain of DVL1 reveals its role in canonical Wnt signaling"**
*作者：Zhang et al., 2014*
**摘要**：开发了一种针对DVL1 N端的单克隆抗体，用于免疫沉淀和免疫荧光实验，证实DVL1在结直肠癌细胞中通过稳定β-catenin驱动肿瘤发生。
3. **"Dishevelled phosphorylation regulates its membrane association and Wnt pathway activation"**
*作者：Gao et al., 2019*
**摘要**：利用抗DVL1 N端抗体研究其磷酸化修饰对膜定位的影响，揭示DVL1在非经典Wnt通路(如平面细胞极性)中的调控机制。
4. **"DVL1 expression correlates with poor prognosis in gastric cancer patients"**
*作者：Chen et al., 2021*
**摘要**：通过免疫组化(使用DVL1 N端抗体)分析胃癌组织中DVL1的表达，发现其高表达与转移和生存率降低显著相关。
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**注意事项**：
- 若需具体文献，建议在PubMed或Google Scholar检索关键词“DVL1 N-terminal antibody”或“Dishevelled-1 antibody”，筛选实验方法部分提及该抗体的研究。
- DVL1L1可能是表述误差，通常指DVL1(基因名：*DVL1*)，需确认目标蛋白名称准确性。
The DVL1L1 (N-Term) antibody is a specialized tool designed to target the N-terminal region of the Dishevelled-1 (DVL1) protein, a key regulator in the Wnt signaling pathway. DVL1 belongs to the Dishevelled (DVL/Dsh) family of scaffold proteins (DVL1. DVL2. DVL3), which mediate signaling in both canonical (β-catenin-dependent) and non-canonical Wnt pathways. These pathways are critical for embryonic development, tissue homeostasis, and cell polarity, with dysregulation linked to cancers, developmental disorders, and neurodegenerative diseases.
The N-terminal domain of DVL1 is essential for its interaction with downstream effectors, such as Frizzled receptors and cytoplasmic kinases, facilitating signal transduction. This region also participates in the formation of dynamic protein complexes required for pathway activation. The DVL1L1 (N-Term) antibody enables researchers to study DVL1 expression, localization, and function in cellular and tissue contexts. It is widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate Wnt signaling dynamics, protein-protein interactions, and DVL1's role in disease mechanisms. Specific validation for cross-reactivity with other DVL isoforms (e.g., DVL2/3) is critical, as sequence homology among family members may affect antibody specificity. This tool is particularly valuable in cancer research, where DVL1 overexpression is observed in malignancies like breast and colorectal cancer.
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