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Rabbit Polyclonal RPL22(C-term) Antibody

  • 中文名: RPL22(C-term)抗体
  • 别    名: 60S ribosomal protein L22, EBER-associated protein, EAP, Epstein-Barr virus small RNA-associated protein, Heparin-binding protein HBp15, RPL22
货号: IPDX33471
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases60S ribosomal protein L22, EBER-associated protein, EAP, Epstein-Barr virus small RNA-associated protein, Heparin-binding protein HBp15, RPL22
Entrez GeneID6146
WB Predicted band size14.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis RPL22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-121 amino acids from the C-terminal region of human RPL22.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于RPL22(C-term)抗体的参考文献示例(内容为示例性概括,非真实文献):

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1. **标题**:*RPL22 C-terminal domain mediates ribosome binding and regulates translation in leukemia*

**作者**:Zhang Y. et al.

**摘要**:研究利用RPL22(C-term)抗体,发现其C端结构域在核糖体结合中的关键作用,并揭示其在白血病细胞中通过调控特定mRNA翻译影响肿瘤发生。

2. **标题**:*Immunohistochemical analysis of RPL22 expression in colorectal cancer using C-terminal specific antibodies*

**作者**:Smith J.L. et al.

**摘要**:通过RPL22(C-term)抗体的免疫组化分析,发现结直肠癌组织中RPL22表达异常下调,提示其可能作为肿瘤抑制因子参与癌症进展。

3. **标题**:*Structural insights into RPL22 C-terminal dynamics by antibody-based probing*

**作者**:Kumar R. & Lee S.

**摘要**:利用RPL22(C-term)抗体结合X射线晶体学,解析C端构象变化对核糖体功能的影响,表明该区域在翻译延伸阶段的动态调控作用。

4. **标题**:*RPL22 interacts with EZH2 via its C-terminal domain: A study co-immunoprecipitation*

**作者**:Chen H. et al.

**摘要**:通过C端特异性抗体的免疫共沉淀实验,证实RPL22与表观调控因子EZH2的相互作用,暗示其在染色质修饰与翻译偶联中的新功能。

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(注:以上文献为示例,实际引用需查询PubMed/Google Scholar等数据库。)

背景信息

The RPL22(C-term) antibody is designed to target the C-terminal region of Ribosomal Protein L22 (RPL22), a component of the 60S ribosomal subunit involved in protein synthesis. RPL22 plays dual roles in cellular processes: as a structural ribosome protein essential for mRNA translation and as an extraribosomal regulator implicated in tumor suppression and immune response. Studies suggest RPL22 dysfunction is linked to cancers, including leukemia and solid tumors, where its loss or mutation may drive oncogenesis. The C-terminal domain is critical for its ribosomal integration and interaction with RNA or protein partners. Antibodies against this region are valuable tools for detecting RPL22 expression levels, localization, and post-translational modifications in research applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They help elucidate RPL22's role in ribosome biogenesis, translational control, and disease mechanisms. Specificity for the C-terminus ensures recognition of full-length RPL22. distinguishing it from potential cleavage products or isoforms. Such antibodies are particularly relevant in cancer research, where RPL22 dysregulation is studied for diagnostic or therapeutic insights. Validation in relevant cell lines or tissues is essential to confirm antibody performance across experimental models.

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