Rabbit Polyclonal PABPC5 Antibody

The poly(A)-binding protein cytoplasmic 5 (PABPC5) is a member of the PABP family, which plays critical roles in post-transcriptional gene regulation by binding to the poly(A) tails of mRNA. PABPC5. also known as PABP5 or embryonic poly(A)-binding protein (ePABP), is primarily expressed in germ cells and during early embryonic development, distinguishing it from other ubiquitously expressed family members like PABPC1. It facilitates mRNA stability, translation initiation, and RNA-protein complex assembly, contributing to gametogenesis and embryogenesis. Antibodies targeting PABPC5 are valuable tools for studying its expression dynamics, subcellular localization, and functional interactions in reproductive biology and developmental models. These antibodies are typically produced in rabbits or mice using immunogenic peptides or recombinant protein fragments. Validation often includes Western blotting, immunohistochemistry, and immunofluorescence to confirm specificity, particularly in differentiating PABPC5 from other PABP isoforms. Research applications span investigations into fertility disorders, early developmental processes, and certain cancers where PABPC5 may be dysregulated. As a less characterized PABP member, PABPC5-specific antibodies also aid in exploring its unique regulatory mechanisms in mRNA metabolism under physiological and pathological conditions.