Rabbit Polyclonal AHI1 Antibody

The AHI1 (Abelson helper integration site 1) antibody is a tool used to study the AHI1 protein, encoded by the *AHI1* gene, which plays a critical role in neuronal and ciliary function. AHI1. also known as Jouberin, is predominantly expressed in the brain, particularly in cerebellar neurons and retinal photoreceptors. It contributes to ciliogenesis, intracellular trafficking, and synaptic connectivity, with implications for neurodevelopment. Mutations in *AHI1* are linked to Joubert syndrome, a rare autosomal recessive disorder characterized by cerebellar hypoplasia, developmental delays, and retinal degeneration. The AHI1 antibody aids in detecting protein expression, localization, and interaction partners in cellular and tissue models, helping elucidate its role in ciliary signaling pathways and neuronal maintenance. Research also explores its potential involvement in cancer, as altered AHI1 expression has been observed in certain tumors. However, its precise mechanisms in oncogenesis remain unclear. The antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence, supporting studies on neurodevelopmental disorders and ciliopathies. Understanding AHI1's function through antibody-based assays provides insights into disease pathogenesis and therapeutic targets.