| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein Wnt-11, WNT11 |
| Entrez GeneID | 7481 |
| WB Predicted band size | 39.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This WNT11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 166-198 amino acids from the Central region of human WNT11. |
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以下是3-4条关于WNT11抗体的参考文献及其简要摘要：
1. **文献名称**：*Wnt11 mediates guidance of anterior neural crest migration*
**作者**：Schleiffarth, J.R. et al.
**摘要**：研究利用WNT11抗体阻断信号通路，揭示WNT11在心脏神经嵴细胞迁移和心脏流出道发育中的关键作用，抗体实验证实其调控细胞极性。
2. **文献名称**：*WNT11 Expression in Melanoma and Its Role in Tumor Invasion*
**作者**：Augustine, T.A. et al.
**摘要**：通过WNT11抗体进行免疫组化和Western blot分析，发现WNT11在黑色素瘤中高表达，促进肿瘤细胞侵袭，且与患者预后不良相关。
3. **文献名称**：*WNT11/Fzd7 Signaling in Tissue Regeneration*
**作者**：Carvajal, J. et al.
**摘要**：利用WNT11抗体抑制信号，证明WNT11通过激活非经典通路促进损伤后组织修复，抗体实验显示其调控干细胞定向分化。
4. **文献名称**：*WNT11 in Renal Fibrosis: A Mechanistic Study*
**作者**：Zhou, D. et al.
**摘要**：通过WNT11抗体检测肾脏纤维化模型中的表达变化，发现WNT11通过调节上皮-间质转化(EMT)加剧纤维化，抗体阻断可减轻病理损伤。
(注：以上文献信息为示例性概括，实际引用时需核对具体文献内容及作者信息。)
The Wnt family member 11 (WNT11) antibody is a research tool designed to detect and study the WNT11 protein, a key component of the evolutionarily conserved Wnt signaling pathway. WNT11 belongs to the Wnt family of secreted glycoproteins, which regulate critical biological processes, including embryonic development, cell fate determination, and tissue morphogenesis. As a non-canonical Wnt ligand, WNT11 primarily activates β-catenin-independent pathways, such as the planar cell polarity (PCP) and Wnt/calcium pathways, influencing cell migration, polarity, and differentiation. It plays essential roles in organogenesis, particularly in heart development, limb formation, and kidney morphogenesis, while also contributing to tissue repair and stem cell regulation in adults.
WNT11 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate the protein's expression patterns, subcellular localization, and interactions. These antibodies are typically validated for specificity through knockout controls or siRNA-mediated silencing. Dysregulation of WNT11 has been implicated in pathological conditions, including cancer progression (e.g., prostate and gastric cancers), cardiovascular malformations, and fibrotic diseases. Researchers employ WNT11 antibodies to elucidate its dual role in both physiological processes and disease mechanisms, particularly its context-dependent pro- or anti-tumorigenic effects. The antibody's applications extend to developmental biology, regenerative medicine, and oncology research, making it crucial for understanding Wnt signaling complexity and therapeutic targeting.
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