| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 5-hydroxytryptamine receptor 1E, 5-HT-1E, 5-HT1E, S31, Serotonin receptor 1E, HTR1E |
| Entrez GeneID | 3354 |
| WB Predicted band size | 41.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HTR1E antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 223-258 amino acids from human HTR1E. |
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以下是关于HTR1E抗体的3篇参考文献示例(内容基于学术文献的典型结构归纳)：
1. **文献名称**：*Development and Characterization of a Selective HTR1E Polyclonal Antibody for Neurotransmitter Receptor Studies*
**作者**：Smith A, Johnson R.
**摘要**：本研究开发了一种针对HTR1E受体的多克隆抗体，并通过免疫印迹和免疫组化验证其特异性。实验证明该抗体可识别HTR1E在人脑组织中的表达，未与其他5-HT受体亚型(如HTR1A/HTR1B)发生交叉反应，适用于神经递质受体的定位研究。
2. **文献名称**：*HTR1E Expression in Glioblastoma: Insights from Antibody-Based Immunohistochemical Analysis*
**作者**：Chen L, Wang Y, Gupta S.
**摘要**：通过使用商业化HTR1E抗体，研究者分析了胶质母细胞瘤组织中HTR1E的蛋白表达水平，发现其表达与肿瘤侵袭性相关，提示HTR1E可能作为神经肿瘤的潜在治疗靶点。研究同时验证了抗体在病理样本中的可靠性。
3. **文献名称**：*Comparative Study of HTR1E Antibody Specificity Across Species Using HEK293 Transfected Cell Models*
**作者**：Müller T, et al.
**摘要**：该文献评估了多种HTR1E抗体在人类、小鼠和大鼠细胞模型中的交叉反应性，发现部分抗体存在种属特异性差异。研究强调了抗体选择对精准研究HTR1E功能的重要性，并提供了验证实验的标准流程。
(注：上述文献为示例性概括，实际引用时需以真实发表的论文为准。)
The HTR1E antibody is a research tool designed to target the 5-hydroxytryptamine (serotonin) receptor 1E (HTR1E or 5-HT1E), a G protein-coupled receptor (GPCR) encoded by the *HTR1E* gene in humans. This receptor binds serotonin (5-HT), a neurotransmitter regulating mood, cognition, and sensory processing. HTR1E is one of 14 serotonin receptor subtypes, distinguished by its high affinity for serotonin and unique expression pattern, primarily observed in the cerebral cortex, hippocampus, and amygdala. Unlike other 5-HT1 receptors (e.g., 5-HT1A or 5-HT1B), HTR1E lacks a defined role in neurotransmission modulation, though it is implicated in neuroprotection and neuroplasticity. Its signaling mechanisms remain less understood but are thought to involve inhibition of adenylate cyclase via Gi/o protein coupling.
HTR1E antibodies are primarily used in neuroscience and pharmacology to map receptor distribution, study expression levels in disease models, and explore ligand-receptor interactions. These antibodies enable techniques like immunohistochemistry, Western blotting, and flow cytometry. Research has linked HTR1E dysregulation to neuropsychiatric disorders (e.g., depression, schizophrenia) and neurodegenerative conditions, though its precise pathophysiological role remains under investigation. Commercially available HTR1E antibodies vary in host species, clonality, and conjugation, requiring validation for specificity due to potential cross-reactivity with homologous receptors. Recent studies also explore HTR1E's potential as a therapeutic target, particularly in migraine and anxiety disorders, driving demand for reliable detection tools. However, the receptor's low abundance and overlapping homology with other 5-HT subtypes pose challenges for antibody development and application.
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