| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nascent polypeptide-associated complex subunit alpha-2, Alpha-NAC-like, Hom s 201, Nascent polypeptide-associated complex subunit alpha-like, NAC-alpha-like, NACA2, NACAL |
| Entrez GeneID | 342538 |
| WB Predicted band size | 23.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This NACA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 36-69 amino acids from human NACA2. |
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以下是基于学术文献常见主题构造的示例参考文献(请注意，部分内容可能为模拟示例，建议通过学术数据库验证具体文献)：
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1. **文献名称**: "NACα2 Antibody Characterization and Its Role in Nascent Chain Binding"
**作者**: Müller, R., et al.
**摘要**: 本研究报道了一种针对NACα2蛋白N端的多克隆抗体的开发与验证，证实其在免疫印迹和免疫荧光中的特异性。研究发现NACα2通过与新生多肽链结合参与内质网靶向，为蛋白质折叠机制提供新见解。
2. **文献名称**: "N-Terminal Antibodies Reveal NACα2 Dysregulation in Breast Cancer"
**作者**: Chen, L., & Wang, H.
**摘要**: 利用NACα2 N端抗体分析乳腺癌组织样本，发现NACα2表达水平与肿瘤进展及患者预后显著相关，提示其可能作为癌症生物标志物。
3. **文献名称**: "Structural Analysis of NAC Complex Using Domain-Specific Antibodies"
**作者**: Tanaka, K., et al.
**摘要**: 通过NACα2 N端抗体和C端抗体的对比实验，揭示NAC复合体的构象变化及其在应激条件下对错误折叠蛋白的调控作用。
4. **文献名称**: "NACα2 Knockout Mouse Model Validated by N-Terminal Antibody Staining"
**作者**: Johnson, E.S., et al.
**摘要**: 研究利用特异性NACα2抗体验证基因敲除模型，证明NACα2缺失导致神经元发育异常，为神经退行性疾病机制提供实验依据。
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建议通过 **PubMed/Google Scholar** 检索关键词如 *"NACα2 antibody N-terminal"* 或 *"NACA2 antibody"* 获取真实文献。如需具体文献协助，请提供更多研究背景。
The NACA2 (N-Term) antibody is a research tool designed to target the N-terminal region of the Nascent Polypeptide-Associated Complex subunit alpha 2 (NACA2), a protein involved in maintaining cellular protein homeostasis. NACA2. part of the NAC complex, binds to ribosomes and interacts with nascent polypeptide chains during translation, aiding in proper protein folding, localization, and protection from aggregation. It plays roles in stress responses, including endoplasmic reticulum (ER) stress, and has been linked to cellular processes like apoptosis and autophagy.
This antibody is widely used in molecular biology to study NACA2 expression, localization, and function via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Researchers employ it to explore NACA2's involvement in diseases like cancer, where dysregulation of protein homeostasis contributes to tumor progression, or neurodegenerative disorders, where misfolded proteins accumulate. Studies also investigate its role in development, as NAC complexes are critical during embryogenesis. By detecting the N-terminal epitope, the antibody helps distinguish NACA2 from homologs like NACA1. enabling precise analysis of isoform-specific interactions. Its applications extend to elucidating mechanisms of stress adaptation, therapeutic targeting of protein-misfolding diseases, and understanding ribosome-associated quality control pathways.
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