Rabbit Polyclonal SRGAP2 Antibody

SRGAP2 (Slit-Robo GTPase-activating protein 2) is a gene encoding a protein involved in regulating neuronal development, particularly in cortical brain evolution and synaptic plasticity. It belongs to the SRGAP family, which modulates cytoskeletal dynamics and cell migration by interacting with Robo receptors and inhibiting downstream signaling. SRGAP2 is notably associated with human-specific brain evolution, as a human-specific duplication (SRGAP2C) emerged ~2-3 million years ago, potentially influencing neocortical expansion and dendritic spine maturation. Antibodies targeting SRGAP2 are crucial tools for studying its expression, localization, and functional roles in neurodevelopmental processes. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate SRGAP2’s involvement in neuronal connectivity, synaptic pruning, and disorders like autism and schizophrenia. Research suggests SRGAP2 influences dendritic spine density and morphology, affecting neural network formation. Its inhibition or overexpression alters synaptic plasticity, linking it to cognitive functions. SRGAP2 antibodies thus aid in exploring mechanisms underlying brain development, evolutionary adaptations, and neurological disease pathways, bridging molecular insights with behavioral and clinical implications.