| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Rhomboid-related protein 1, RRP, Rhomboid-like protein 1, RHBDL1, RHBDL |
| Entrez GeneID | 9028 |
| WB Predicted band size | 48.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This RHBDL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 148-182 amino acids from the Central region of human RHBDL1. |
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以下是关于RHBDL1抗体的3篇参考文献示例(注：文献为模拟示例，实际引用时请核实真实来源)：
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1. **文献名称**: *"RHBDL1-mediated shedding of pro-TGF-α regulates EGFR signaling and cell migration"*
**作者**: Urban, S., et al.
**摘要**: 本研究利用特异性RHBDL1抗体，揭示了该蛋白酶通过切割TGF-α前体(pro-TGF-α)调控EGFR信号通路的机制。实验表明，RHBDL1的活性缺失(通过抗体阻断验证)会抑制肿瘤细胞的迁移能力。
2. **文献名称**: *"Development and validation of a monoclonal antibody for RHBDL1 in human tissues"*
**作者**: Smith, J., Lee, H., & Zhang, Y.
**摘要**: 文章报道了一种针对人源RHBDL1的单克隆抗体的开发，并通过免疫印迹(Western blot)和免疫组化验证其特异性。该抗体被用于检测RHBDL1在正常与癌变组织中的差异表达。
3. **文献名称**: *"RHBDL1 promotes angiogenesis via cleavage of EphB4 extracellular domain"*
**作者**: Wang, Q., et al.
**摘要**: 研究利用RHBDL1抗体阻断实验，证明RHBDL1通过剪切EphB4受体调控血管生成。抗体介导的功能抑制显著降低了内皮细胞的管腔形成能力。
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**备注**：以上文献为示例，实际研究中建议通过PubMed或Web of Science等数据库，以关键词“RHBDL1 antibody”或“RHBDL1 inhibitor”检索最新成果，并注意选择高影响力期刊的论文。
The RHBDL1 antibody is a tool used to study the rhomboid-like protein 1 (RHBDL1), a member of the rhomboid protease family. Rhomboid proteases are intramembrane serine proteases that cleave transmembrane substrates, regulating diverse cellular processes such as cell signaling, adhesion, and protein trafficking. RHBDL1. located on the cell surface or in secretory pathways, is implicated in modulating extracellular protein interactions, including the cleavage of epidermal growth factor (EGF) ligands and other membrane-tethered signaling molecules. This activity influences pathways like EGFR signaling, which plays roles in cell proliferation, differentiation, and cancer progression.
Antibodies targeting RHBDL1 enable researchers to investigate its expression, localization, and function in various tissues and disease models. They are commonly used in techniques like Western blotting, immunohistochemistry, and flow cytometry. Studies using RHBDL1 antibodies have revealed its upregulated expression in certain cancers, suggesting potential roles in tumorigenesis or metastasis. Additionally, RHBDL1 is linked to developmental processes and immune regulation, though its precise mechanisms remain under exploration. The antibody's specificity and validation (e.g., knockout controls) are critical to ensure accurate detection, given the structural similarities among rhomboid family members. Overall, RHBDL1 antibodies serve as essential reagents for unraveling the biological and pathological significance of this enigmatic protease.
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