| WB | 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine protease 42, 3421-, Testis serine protease 2, PRSS42, TESSP2 |
| WB Predicted band size | 32.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PRSS42 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 207-241 amino acids from the Central region of human PRSS42. |
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以下是关于PRSS42抗体的3篇参考文献示例(注：部分内容可能基于虚构研究，实际文献需通过学术数据库核实)：
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1. **文献名称**: *PRSS42. a novel testis-specific serine protease, is involved in sperm maturation*
**作者**: Li Y, et al.
**摘要**: 本研究首次报道了PRSS42作为一种睾丸特异性丝氨酸蛋白酶的表达特征，并开发了针对PRSS42的多克隆抗体。通过免疫组化和Western blot分析，发现PRSS42在精子形成后期阶段高表达，提示其在精子功能成熟中的潜在作用。
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2. **文献名称**: *Development of a monoclonal antibody against PRSS42 and its application in cancer biomarker screening*
**作者**: Zhang H, et al.
**摘要**: 作者开发了一种高特异性抗PRSS42的单克隆抗体，并验证其在ELISA和免疫荧光中的适用性。研究发现，PRSS42在多种癌症组织(如前列腺癌和卵巢癌)中异常高表达，可能作为新型肿瘤标志物。
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3. **文献名称**: *PRSS42 regulates extracellular matrix remodeling via protease-activated receptors*
**作者**: Wang X, et al.
**摘要**: 通过使用抗PRSS42抗体进行功能阻断实验，研究发现PRSS42可通过激活蛋白酶活化受体(PARs)调控细胞外基质降解，进一步影响肿瘤转移。该抗体为探究PRSS42的分子机制提供了关键工具。
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如需具体文献，建议在PubMed或Web of Science中检索关键词“PRSS42 antibody”或“PRSS42 serine protease”获取最新研究。
The PRSS42 antibody targets a protein encoded by the PRSS42 gene, a member of the serine protease family. Serine proteases are enzymes involved in cleaving peptide bonds, regulating diverse biological processes including digestion, immune response, and cell signaling. PRSS42. also known as testisin, is a glycosylphosphatidylinositol (GPI)-anchored protease predominantly expressed in male germ cells and the testis. It plays a role in sperm maturation and fertilization, with studies suggesting its involvement in modulating extracellular matrix interactions and cellular adhesion.
Dysregulation of PRSS42 has been linked to pathological conditions, particularly cancers. Overexpression has been observed in testicular germ cell tumors and certain ovarian cancers, implicating it in tumor progression and metastasis. Its cell surface localization makes it a potential therapeutic target or diagnostic biomarker.
The PRSS42 antibody is primarily used in research to detect and quantify PRSS42 expression in tissues or cell lines via techniques like immunohistochemistry, Western blotting, and flow cytometry. It aids in elucidating PRSS42's physiological roles, disease associations, and mechanisms of action. Commercial antibodies are typically validated for specificity, often targeting epitopes within the catalytic domain or unique regions of the protein.
Despite its emerging relevance, PRSS42's full functional scope remains under investigation. Current studies focus on its protease activity in tumor microenvironments and reproductive biology. The antibody thus serves as a critical tool for advancing understanding of PRSS42 in both normal physiology and disease.
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