| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Chymase, Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM |
| Entrez GeneID | 1215 |
| WB Predicted band size | 27.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CMA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-118 amino acids from human CMA1. |
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以下是关于CMA1(N-Term)抗体的3篇参考文献的简要列举：
1. **文献名称**：*"Characterization of a Novel Anti-Chymase 1 (N-Term) Antibody for Detecting Mast Cell Activation in Cardiovascular Tissues"*
**作者**：Smith J, et al.
**摘要**：本研究开发并验证了一种针对CMA1蛋白N端结构域的高特异性单克隆抗体。通过免疫组化和Western blot分析，证实该抗体可有效检测人及小鼠心血管组织肥大细胞中Chymase 1的表达，并用于评估心肌纤维化模型中的肥大细胞活化状态。
2. **文献名称**：*"Role of Chymase in Renal Fibrosis: Insights from N-Terminal Specific Antibody Staining"*
**作者**：Li Y, et al.
**摘要**：利用抗CMA1(N-Term)抗体，研究者揭示了Chymase 1在慢性肾病模型肾组织中的分布及表达上调现象。抗体特异性通过基因敲除小鼠验证，结果显示Chymase 1通过促进TGF-β通路加剧纤维化进程。
3. **文献名称**：*"Development of a Sensitive ELISA Using Anti-CMA1 (N-Term) Antibody for Early Detection of Allergic Inflammation"*
**作者**：Tanaka K, et al.
**摘要**：该文献报道了一种基于CMA1(N-Term)抗体的ELISA检测方法，能够高灵敏度量化血清中Chymase 1水平，用于哮喘和过敏性皮炎患者的炎症标志物分析，为临床诊断提供新工具。
(注：上述文献为示例性内容，实际引用需根据真实研究调整。)
The CMA1 (N-Term) antibody is designed to detect chymase 1 (CMA1), a serine protease predominantly expressed in mast cells. CMA1. also known as mast cell chymase, plays a critical role in inflammatory responses, tissue remodeling, and extracellular matrix degradation by cleaving substrates such as angiotensin I, cytokines, and matrix proteins. Its N-terminal region contains conserved structural motifs essential for enzymatic activity and interaction with cellular components. The CMA1 (N-Term) antibody specifically targets epitopes within this region, enabling precise detection of the full-length or mature form of the enzyme in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.
Research using this antibody has advanced understanding of mast cell biology in conditions like allergic disorders, fibrosis, cardiovascular diseases, and cancer. By distinguishing CMA1 from other chymotryptic enzymes (e.g., cathepsin G), it helps elucidate its unique contributions to pathological processes. Validated for specificity and sensitivity, the antibody is a key tool for studying mast cell activation, protease-mediated signaling, and therapeutic targeting of CMA1 in preclinical models. Its utility extends to both basic research and drug development, underscoring its importance in exploring inflammation-related pathways and mast cell-driven pathologies.
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