| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Endophilin-A3, EEN-B2, Endophilin-3, SH3 domain protein 2C, SH3 domain-containing GRB2-like protein 3, SH3GL3, CNSA3, SH3D2C |
| Entrez GeneID | 6457 |
| WB Predicted band size | 39.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This SH3GL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 290-325 amino acids from the C-terminal region of human SH3GL3. |
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以下是关于SH3GL3抗体的模拟参考文献示例(注：文献为虚构，仅作格式参考)：
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1. **文献名称**: *SH3GL3 Antibody Characterization in Neuronal Endocytosis*
**作者**: Miller, J. et al.
**摘要**: 本研究利用特异性SH3GL3抗体探究其在神经元突触囊泡内吞中的作用。通过免疫印迹和免疫荧光证实抗体特异性，发现SH3GL3与突触蛋白动态调控相关，提示其在神经信号传递中的关键功能。
2. **文献名称**: *SH3GL3 Expression Profiling in Glioblastoma Using a Novel Monoclonal Antibody*
**作者**: Chen, L. et al.
**摘要**: 开发了一种新型抗SH3GL3单克隆抗体，并验证其在人胶质母细胞瘤组织中的结合能力。研究发现SH3GL3低表达与肿瘤侵袭性相关，为癌症预后提供了潜在标志物。
3. **文献名称**: *SH3GL3 Antibody Reveals Isoform-Specific Roles in Membrane Remodeling*
**作者**: Gupta, R. et al.
**摘要**: 通过SH3GL3特异性抗体区分不同剪接变体，发现其亚型在细胞膜形态调控中的差异功能，为内吞途径的分子机制提供了新见解。
4. **文献名称**: *Autoantibody Targeting SH3GL3 in Autoimmune Disorders*
**作者**: Park, S. et al.
**摘要**: 研究在系统性红斑狼疮患者血清中检测到抗SH3GL3自身抗体，提示其可能参与自身免疫反应的病理过程，为疾病诊断提供了新方向。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“SH3GL3 antibody”或结合具体研究领域筛选。
The SH3GL3 antibody targets the SH3 domain-containing GRB2-like protein 3 (SH3GL3), a member of the endophilin family involved in membrane remodeling and intracellular trafficking. SH3GL3. also known as endophilin A3. contains an N-terminal BAR domain that binds curved membranes and a C-terminal SH3 domain mediating protein-protein interactions, particularly with dynamin and synaptojanin to regulate clathrin-mediated endocytosis. It is predominantly expressed in the brain, where it facilitates synaptic vesicle recycling and neuronal signaling.
SH3GL3 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. Researchers use these antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore SH3GL3's role in neurological disorders, such as Alzheimer's disease, and cancer, where its dysregulation may influence tumor progression. Some studies suggest SH3GL3 acts as a tumor suppressor in certain cancers due to reduced expression in malignant tissues.
Antibody specificity is critical, as SH3GL3 shares structural homology with other endophilin isoforms (A1. A2). Validated antibodies help distinguish SH3GL3's unique roles in cellular processes, including apoptosis, autophagy, and receptor tyrosine kinase signaling. Its interaction with ESCRT machinery further links it to membrane scission and viral budding pathways. Overall, SH3GL3 antibodies are vital for deciphering its contributions to cell biology and disease mechanisms.
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