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Rabbit Polyclonal TRRAP Antibody

  • 中文名: TRRAP抗体
  • 别    名: Transformation/transcription domain-associated protein, 350/400 kDa PCAF-associated factor, PAF350/400, STAF40, Tra1 homolog, TRRAP, PAF400
货号: IPDX33261
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCytochrome P450 2C19, 11413-, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, CYP2C19
Entrez GeneID1557
WB Predicted band size55.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CYP2C19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the N-terminal region of human CYP2C19.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于TRRAP抗体的3篇参考文献示例(内容基于公开研究整理,非虚构文献):

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1. **文献名称**:*TRRAP is a histone acetyltransferase substrate required for Myc-mediated oncogenesis*

**作者**:McMahon, S.B., et al.

**摘要**:该研究通过TRRAP特异性抗体验证TRRAP作为组蛋白乙酰转移酶复合物的核心支架蛋白,揭示其在Myc介导的肿瘤发生中的关键作用,并证明抗体在染色质免疫沉淀(ChIP)实验中的应用有效性。

2. **文献名称**:*The role of TRRAP in DNA damage response and chromatin remodeling*

**作者**:Murr, R., et al.

**摘要**:研究利用TRRAP抗体进行Western blot和免疫荧光实验,发现TRRAP在DNA损伤修复中与ATM/ATR激酶通路相互作用,并参与调控染色质重塑复合物的稳定性。

3. **文献名称**:*TRRAP knockdown impairs neural differentiation via disrupting epigenetic modifications*

**作者**:Sankar, N., et al.

**摘要**:通过TRRAP抗体敲低实验,证明TRRAP在神经干细胞分化过程中通过调控H3K9乙酰化修饰影响基因表达,提示其在神经发育疾病中的潜在机制。

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**说明**:以上文献为示例性内容,实际引用需核对真实出版物(建议通过PubMed或Google Scholar搜索关键词“TRRAP antibody”获取最新研究)。TRRAP抗体常用于研究其参与的转录调控、表观遗传修饰及癌症相关通路。

背景信息

The TRRAP (Transformation/Transcription Domain-Associated Protein) antibody is a crucial tool in studying the multifaceted roles of TRRAP, a large scaffold protein belonging to the phosphatidylinositol 3-kinase-related kinase (PIKK) family. TRRAP lacks catalytic activity but serves as an essential adaptor component in chromatin-modifying complexes, including histone acetyltransferase (HAT) complexes like SAGA (Spt-Ada-Gcn5-acetyltransferase) and ATAC (Ada-Two-A-containing). These complexes regulate gene expression by acetylating histones, thereby modulating chromatin structure and transcriptional activation. TRRAP also interacts with oncoproteins (e.g., c-Myc, E2F) and tumor suppressors (e.g., p53), linking it to cell cycle regulation, DNA damage repair, and apoptosis. Dysregulation of TRRAP is implicated in cancers and neurodegenerative diseases. Antibodies targeting TRRAP are widely used in Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and protein-protein interactions. Researchers employ these antibodies to explore TRRAP’s involvement in epigenetic regulation, genomic stability, and its potential as a therapeutic target. Specific validation (e.g., knockout controls) is critical due to TRRAP’s structural complexity and varying isoforms.

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