Rabbit Polyclonal MAML2 Antibody

The MAML2 (Mastermind-like protein 2) antibody is a tool used to detect the MAML2 protein, a critical transcriptional co-activator in the Notch signaling pathway. MAML2 belongs to the Mastermind-like family, which interacts with the intracellular domain of Notch receptors and CSL (CBF1/RBP-Jκ, Su(H), Lag-1) transcription factors to regulate target gene expression. This pathway plays essential roles in cell differentiation, proliferation, and survival, with dysregulation linked to cancers, including mucoepidermoid carcinoma and lung adenocarcinoma. MAML2 is notably involved in chromosomal translocations, such as the CRTC1-MAML2 fusion oncogene, a hallmark of salivary gland and other tumors. Antibodies targeting MAML2 are widely used in research and diagnostics to study Notch signaling dynamics, tumorigenesis, and molecular classification of fusion-driven cancers. They enable detection of endogenous MAML2 expression or fusion proteins via techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence. Commercial MAML2 antibodies are typically validated for specificity against human, mouse, or rat samples, aiding in both basic research and clinical applications, such as identifying MAML2 rearrangements in tumor samples. Ongoing studies focus on its role in therapeutic resistance and as a potential biomarker for targeted therapies.