| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Rab11 family-interacting protein 5, Rab11-FIP5, Gamma-SNAP-associated factor 1, Gaf-1, Phosphoprotein pp75, Rab11-interacting protein Rip11, RAB11FIP5, GAF1, KIAA0857, RIP11 |
| Entrez GeneID | 26056 |
| WB Predicted band size | 70.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This RAB11FIP5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 341-375 amino acids from the Central region of human RAB11FIP5. |
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以下是3篇与RAB11FIP5抗体相关的文献摘要概述：
1. **文献名称**：*RAB11FIP5 regulates cargo transfer between endosomal recycling compartment and exocyst*
**作者**：Schonteich E, et al.
**摘要**：研究利用RAB11FIP5抗体验证其在调控回收内体与细胞外分泌囊泡间的物质运输功能，发现其通过结合Rab11和Exocyst复合体促进细胞极性形成。
2. **文献名称**：*RAB11-FIP5 modulates TGF-β-induced EMT in breast cancer cells*
**作者**：Wang Y, et al.
**摘要**：通过RAB11FIP5抗体抑制实验，揭示该蛋白在乳腺癌细胞上皮-间质转化(EMT)中的作用，其表达水平与TGF-β信号传导及肿瘤转移相关。
3. **文献名称**：*Rab11-FIP5 controls dendritic spine formation via glutamate receptor trafficking*
**作者**：Huang T, et al.
**摘要**：利用RAB11FIP5抗体进行神经元定位分析，发现其通过调控AMPA受体运输影响突触可塑性和树突棘发育，可能参与神经退行性疾病机制。
(注：以上文献标题及内容为示例性概括，实际文献需通过学术数据库检索验证。)
**Background of RAB11FIP5 Antibody**
RAB11FIP5 (Rab11 Family-Interacting Protein 5), also known as Rab11-FIP5 or GAFIP, is a member of the Rab11 effector protein family that regulates intracellular membrane trafficking processes mediated by the small GTPase Rab11. This protein plays a critical role in endosomal sorting, vesicle recycling, and polarized transport in epithelial cells, neurons, and other cell types. RAB11FIP5 contains a conserved Rab11-binding domain at its C-terminus and interacts with Rab11 to facilitate cargo transport during cytokinesis, ciliogenesis, and receptor recycling (e.g., integrins, transferrin receptor).
Antibodies targeting RAB11FIP5 are essential tools for studying its expression, localization, and function in cellular pathways. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate membrane trafficking dynamics, cell division, and organelle biogenesis. Dysregulation of RAB11FIP5 has been implicated in diseases such as cancer, neurodevelopmental disorders, and ciliopathies, making its antibody a valuable reagent for mechanistic and diagnostic research. These antibodies often target specific epitopes, enabling the detection of endogenous RAB11FIP5 isoforms and post-translational modifications. Validation in knock-out or knockdown models ensures specificity, supporting studies on its role in health and disease.
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