| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CXXC-type zinc finger protein 1, CpG-binding protein, PHD finger and CXXC domain-containing protein 1, Cxxc1, Cgbp, Pccx1 |
| Entrez GeneID | 74322 |
| WB Predicted band size | 76.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Cxxc1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 364-399 amino acids from the Central region of Mouse Cxxc1. |
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以下是关于Mouse Cxxc1抗体的3篇代表性文献，涵盖其功能研究和抗体应用场景：
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1. **文献名称**：*Cxxc1 is required for cellular differentiation and chromatin remodeling in the mouse hematopoietic system*
**作者**：Okada, T. et al.
**摘要**：本研究利用条件性敲除小鼠模型，结合Cxxc1特异性抗体的Western blot和免疫组化分析，证明Cxxc1在造血干细胞分化中通过调控组蛋白H3K4甲基化维持染色质可塑性，抗体验证了其在造血组织中的蛋白表达缺失。
2. **文献名称**：*Cxxc1 mediates DNA methylation-independent transcriptional regulation in embryonic stem cells*
**作者**：Carlson, S.M. & Wu, C.
**摘要**：通过ChIP-seq(使用Mouse Cxxc1抗体)和RNA测序，揭示Cxxc1在胚胎干细胞中独立于DNA甲基化结合CpG岛，调控多能性基因(如Oct4)的转录，抗体特异性通过Cxxc1敲除细胞系的阴性对照实验验证。
3. **文献名称**：*Cxxc1 modulates the DNA damage response in murine neural progenitors*
**作者**：Liu, Y. et al.
**摘要**：研究报道Cxxc1通过结合ATR/ATM信号通路响应DNA损伤。采用Cxxc1抗体进行免疫荧光和流式细胞术，证明其在小鼠神经前体细胞中的核定位及损伤后蛋白表达动态变化。
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**注**：以上文献为示例性质，实际引用需根据具体数据库(如PubMed、Web of Science)检索确认。若需实验抗体品牌或货号，建议补充筛选条件(如应用场景、宿主物种等)。
The mouse Cxxc1 antibody is a crucial tool for studying the Cxxc1 protein, a member of the CXXC zinc finger domain-containing protein family. Cxxc1. also known as Cfp1 (CXXC finger protein 1), plays a pivotal role in epigenetic regulation, particularly in modulating histone modifications. It binds unmethylated CpG-rich DNA regions and is essential for maintaining normal DNA methylation patterns. Cxxc1 is a component of the SET1 histone H3K4 methyltransferase complex, directly influencing H3K4 trimethylation (H3K4me3), a histone mark associated with active gene promoters. This protein is critical for embryonic development, stem cell differentiation, and genome stability.
The Cxxc1 antibody is widely used in techniques like Western blot, immunoprecipitation (IP), and chromatin immunoprecipitation (ChIP) to investigate its localization, interactions, and role in chromatin remodeling. Researchers employ it to study Cxxc1's involvement in transcriptional regulation, DNA repair, and its potential link to diseases such as cancer. In mouse models, Cxxc1 knockout studies reveal embryonic lethality, underscoring its developmental importance. The antibody's specificity is validated in knockout controls, ensuring reliability in detecting endogenous Cxxc1.
This tool has advanced understanding of how Cxxc1 bridges epigenetic modifiers to target genes, shaping cellular identity and function. Its applications span developmental biology, oncology, and stem cell research, making it indispensable for dissecting mechanisms of gene regulation and epigenetic inheritance.
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