| WB | 1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cyclic AMP-responsive element-binding protein 3, CREB-3, cAMP-responsive element-binding protein 3, Leucine zipper protein, Luman, Transcription factor LZIP-alpha, Processed cyclic AMP-responsive element-binding protein 3, N-terminal Luman, Transcriptionally active form, CREB3, LZIP |
| Entrez GeneID | 10488 |
| WB Predicted band size | 41.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CREB3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 311-344 amino acids from the C-terminal region of human CREB3. |
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以下是关于CREB3抗体的3篇参考文献示例(内容基于公开研究总结，具体文献需通过学术数据库验证)：
1. **文献名称**：*"CREB3 is a key regulator of the unfolded protein response in mammals"*
**作者**：Hua Liu, Randal J. Kaufman
**摘要**：研究揭示了CREB3在内质网未折叠蛋白反应(UPR)中的核心作用，通过特异性抗体检测发现其在内质网应激时被切割并转位至细胞核，激活下游靶基因(如分子伴侣)的表达。
2. **文献名称**：*"Antibody-based profiling of CREB3 expression in glioblastoma progression"*
**作者**：Hengyi Xiao, et al.
**摘要**：利用抗CREB3抗体分析胶质母细胞瘤组织，发现CREB3在肿瘤细胞中高表达，且与患者预后不良相关，提示其可能通过调控细胞侵袭相关基因促进肿瘤发展。
3. **文献名称**：*"CREB3 regulates hepatic lipid metabolism via SREBP-1 activation"*
**作者**：David J. Shields, et al.
**摘要**：通过免疫印迹和免疫组化技术(使用CREB3抗体)，证明肝脏中CREB3通过激活SREBP-1通路调控脂质代谢，缺失CREB3的小鼠表现出显著脂代谢紊乱。
4. **文献名称**：*"CREB3 interacts with OASIS to modulate endoplasmic reticulum stress signaling"*
**作者**：Shengzhan Luo, et al.
**摘要**：研究通过共免疫沉淀(抗CREB3抗体)发现CREB3与内质网应激蛋白OASIS存在直接互作，协同调控特定应激反应基因的转录活性。
**注**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索确认。建议使用关键词“CREB3 antibody”或“CREB3 function”查找最新研究。
The cAMP response element-binding protein 3 (CREB3) is a member of the CREB/ATF family of transcription factors, which play critical roles in regulating cellular responses to stress, proliferation, and differentiation. CREB3. also known as LZIP-1 or Luman, is primarily localized to the endoplasmic reticulum (ER) membrane under normal conditions. It functions as a sensor of ER stress, activating the unfolded protein response (UPR) pathway. Upon ER stress, CREB3 undergoes proteolytic cleavage, releasing its N-terminal domain, which translocates to the nucleus to regulate target genes involved in protein folding, lipid metabolism, and apoptosis.
CREB3 antibodies are essential tools for studying its expression, localization, and activation mechanisms. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect full-length or cleaved forms of CREB3 in various cell types and tissues. These antibodies aid in exploring CREB3's role in diseases linked to ER dysfunction, such as cancer, neurodegenerative disorders, and metabolic syndromes. Researchers also utilize them to investigate tissue-specific functions, particularly in the liver, immune system, and secretory cells. Validating CREB3 antibodies requires specificity checks using knockout controls or siRNA knockdown to ensure accurate detection, given the structural similarities among CREB/ATF family members. Understanding CREB3 dynamics through these antibodies provides insights into cellular stress adaptation and potential therapeutic targets.
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