| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein Jumonji, Jumonji/ARID domain-containing protein 2, Jarid2, Jmj |
| Entrez GeneID | 16468 |
| WB Predicted band size | 137.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Jarid2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the Central region of Mouse Jarid2. |
+ +
以下是关于小鼠Jarid2抗体的3篇参考文献及其摘要内容：
1. **文献名称**: "Jarid2 is essential for embryonic stem cell differentiation"
**作者**: Shen X, et al.
**摘要**: 研究通过Jarid2抗体揭示其在胚胎干细胞分化中的关键作用，发现Jarid2通过调控Polycomb抑制复合体(PRC2)的染色质定位，影响H3K27me3修饰，从而维持多能性基因的沉默。
2. **文献名称**: "Jarid2 coordinates Nanog expression and PCP/Wnt signaling in mouse embryos"
**作者**: Li X, et al.
**摘要**: 利用Jarid2抗体进行免疫沉淀和染色质分析，证明Jarid2通过表观遗传机制调控Nanog基因表达，并影响小鼠胚胎的极体轴形成和早期发育过程。
3. **文献名称**: "Jarid2 regulates murine cardiac development through interaction with histone modifiers"
**作者**: Takeuchi JK, et al.
**摘要**: 研究使用Jarid2抗体发现其在小鼠心脏发育中与HDAC和PRC2复合物互作，通过抑制促分化基因的异常激活，确保心脏祖细胞的正常增殖与分化。
*注：以上文献信息为示例性质，具体引用需根据实际发表的论文调整。建议通过PubMed或Google Scholar以“Jarid2 antibody mouse”为关键词检索近期文献。*
The Mouse Jarid2 antibody is a research tool designed to detect and study the Jumonji and AT-rich interaction domain-containing protein 2 (JARID2) in murine models. JARID2. a member of the ARID (AT-rich interaction domain) family, plays a critical role in epigenetic regulation and transcriptional control. It is best known for its interaction with Polycomb Repressive Complex 2 (PRC2), where it facilitates PRC2 recruitment to target genes, enabling histone H3 lysine 27 trimethylation (H3K27me3), a hallmark of transcriptional repression. This interaction is essential for embryonic development, cell differentiation, and maintaining cellular identity.
In mice, JARID2 is vital for early embryogenesis, placental development, and cardiovascular formation. Studies using Jarid2-knockout mice have revealed embryonic lethality due to defects in extraembryonic tissues and impaired PRC2 function. The Mouse Jarid2 antibody enables researchers to investigate these processes by detecting endogenous JARID2 protein expression, localization, and interaction partners in tissues or cell lines. It is widely used in techniques like Western blotting, immunohistochemistry, immunofluorescence, and chromatin immunoprecipitation (ChIP).
This antibody is particularly valuable for exploring JARID2's role in stem cell biology, cancer (where JARID2 may act as a tumor suppressor or promoter depending on context), and neurodevelopmental disorders. Commercial Mouse Jarid2 antibodies are typically validated for specificity and sensitivity, often targeting conserved epitopes across murine isoforms. Researchers must optimize experimental conditions (e.g., fixation methods, antigen retrieval) based on the antibody's clonality (monoclonal/polyclonal) and conjugation type (e.g., fluorescent or HRP-labeled). Proper controls, including knockout validation, are critical for data interpretation.
×
