| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Granzyme K, 3421-, Fragmentin-3, Granzyme-3, NK-tryptase-2, NK-Tryp-2, GZMK, TRYP2 |
| Entrez GeneID | 3003 |
| WB Predicted band size | 28.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This GZMK antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 87-121 amino acids from the human region of human GZMK. |
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以下是关于GZMK(N-Term)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *Granzyme K modulates T cell functions and inhibits viral replication*
**作者**: Smith A, et al.
**摘要**: 本研究利用GZMK(N-Term)抗体通过Western blot和流式细胞术分析，发现GZMK在CD8+ T细胞中高表达，并通过切割特定底物调控T细胞介导的炎症反应。抗体验证显示其对N端表位的高特异性。
2. **文献名称**: *Development and validation of a novel anti-GZMK monoclonal antibody for immune profiling*
**作者**: Chen L, et al.
**摘要**: 文章报道了一种针对GZMK N端区域的新型单克隆抗体的开发。通过ELISA、免疫荧光和免疫沉淀实验验证其灵敏度和特异性，证明其适用于肿瘤微环境中免疫细胞活化的检测。
3. **文献名称**: *Granzyme K expression correlates with chronic inflammation in autoimmune disorders*
**作者**: Kim J, et al.
**摘要**: 利用GZMK(N-Term)抗体对类风湿关节炎患者的组织样本进行免疫组化分析，发现GZMK在炎症部位浸润的NK细胞中显著上调，提示其可能作为自身免疫疾病的潜在生物标志物。
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注：以上文献为示例，实际引用时需核对真实来源及内容准确性。建议通过PubMed或Web of Science以关键词“GZMK antibody N-terminal”进一步检索最新研究。
The GZMK (N-Term) antibody targets the N-terminal region of human granzyme K (GZMK), a serine protease primarily expressed in cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Granzyme K is a key mediator of immune responses, playing roles in apoptosis induction, inflammation regulation, and extracellular matrix remodeling. Unlike granzyme B (GZMB), which activates caspase-dependent apoptosis, GZMK induces cell death via caspase-independent pathways, such as mitochondrial disruption or single-stranded DNA damage. It is also implicated in pro-inflammatory cytokine production and immune cell recruitment, contributing to chronic inflammatory and autoimmune conditions like rheumatoid arthritis or sepsis.
The GZMK (N-Term) antibody is widely used in research to study protein expression, localization, and function in immune cells and disease models. It enables detection of GZMK in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Researchers utilize this antibody to explore GZMK's dual roles in host defense and pathological inflammation, its interaction with extracellular substrates, and its potential as a therapeutic target or biomarker in immune-related disorders. Specificity for the N-terminal region ensures recognition of full-length or processed forms, aiding mechanistic studies of GZMK activation and regulation.
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