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Rabbit Polyclonal (Mouse)Uhrf2 Antibody

  • 中文名： (Mouse) Uhrf2抗体
  • 别    名： E3 ubiquitin-protein ligase UHRF2, 632-, NIRF, Np95-like ring finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, Ubiquitin-like PHD and RING finger domain-containing protein 2, Ubiquitin-like-containing PHD and RING finger domains prote
货号: IPDX33171
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesE3 ubiquitin-protein ligase UHRF2, 632-, NIRF, Np95-like ring finger protein, Nuclear protein 97, Nuclear zinc finger protein Np97, Ubiquitin-like PHD and RING finger domain-containing protein 2, Ubiquitin-like-containing PHD and RING finger domains protein 2, Uhrf2, Nirf
Entrez GeneID109113
WB Predicted band size90.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis Mouse Uhrf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 472-505 amino acids from the Central region of Mouse Uhrf2.

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参考文献

以下是关于小鼠UHRF2抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：

1. **文献名称**: "UHRF2 regulates apoptosis and cell cycle in mouse embryonic fibroblasts via histone modification"

**作者**: Zhang Y, et al.

**摘要**: 该研究利用UHRF2特异性抗体进行ChIP-seq分析，发现UHRF2通过调控组蛋白H3K9me3修饰，影响小鼠胚胎成纤维细胞中细胞周期相关基因(如Cyclin D1)的表达，从而调控细胞增殖与凋亡。

2. **文献名称**: "Dynamic role of UHRF2 in DNA methylation maintenance during mouse embryogenesis"

**作者**: Li H, et al.

**摘要**: 通过Western blot和免疫荧光技术(使用抗UHRF2抗体)，研究揭示UHRF2与DNMT1协同作用，在早期胚胎发育中维持DNA甲基化模式，敲除UHRF2导致胚胎发育异常及甲基化紊乱。

3. **文献名称**: "Uhrf2 deficiency promotes genomic instability and spontaneous tumors in mice"

**作者**: Wang X, et al.

**摘要**: 构建Uhrf2敲除小鼠模型，利用UHRF2抗体验证蛋白缺失，发现UHRF2缺失导致DNA修复缺陷和基因组不稳定性，显著增加淋巴瘤和肉瘤发生率，提示其肿瘤抑制功能。

**注**：以上文献为模拟示例，实际引用时需查询具体数据库(如PubMed)获取真实文献。建议使用关键词“UHRF2 antibody mouse”或“Uhrf2 murine epigenetic”进行检索，并筛选实验方法部分明确使用该抗体的研究。

背景信息

The mouse Uhrf2 (Ubiquitin-like with PHD and RING Finger Domains 2) antibody is a tool used to study the Uhrf2 protein, a member of the UHRF family implicated in epigenetic regulation. Uhrf2. also known as NIRF (Np95/ICBP90-like RING finger protein), shares structural homology with Uhrf1. including conserved domains like the SRA (SET- and RING-associated) domain, PHD finger, and RING finger. However, Uhrf2 exhibits distinct functions, primarily linked to gene silencing, chromatin remodeling, and cell cycle regulation. Unlike Uhrf1. which is critical for DNA methylation maintenance during replication, Uhrf2 is involved in transcriptional repression through interactions with histone modifiers like histone deacetylases (HDACs) and polycomb group proteins. It plays roles in DNA damage response, apoptosis, and embryonic development. Researchers use Uhrf2 antibodies in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions with epigenetic regulators. These studies are vital for understanding Uhrf2's role in diseases, including cancer, where its dysregulation may affect tumor suppression or oncogenic pathways. Validated antibodies typically target specific epitopes, and their specificity is confirmed via knockout controls or siRNA knockdown. The antibody’s utility extends to developmental biology and neurobiology, as Uhrf2 is implicated in neural differentiation and brain function.

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