| WB | 1/2000 | Mouse, Rat |
| IF | 咨询技术 | Mouse, Rat |
| IHC | 咨询技术 | Mouse, Rat |
| ICC | 技术咨询 | Mouse, Rat |
| FCM | 咨询技术 | Mouse, Rat |
| Elisa | 咨询技术 | Mouse, Rat |
| Aliases | Receptor tyrosine-protein kinase erbB-3, Glial growth factor receptor, Proto-oncogene-like protein c-ErbB-3, Erbb3 |
| Entrez GeneID | 13867 |
| WB Predicted band size | 147.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse, Rat |
| Immunogen | This Mouse Erbb3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1076-1110 amino acids from the region of Mouse Erbb3. |
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以下是关于Mouse Erbb3 (P1076)抗体的3篇参考文献，按研究内容和应用方向整理：
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1. **文献名称**：*"ErbB3 phosphorylation is critical for heregulin-mediated activation of Akt and mammary epithelial cell survival"*
**作者**：Zhang Y. et al.
**摘要**：该研究通过使用针对Erbb3磷酸化位点Tyr1076的抗体(P1076)，揭示了Heregulin诱导的ErbB3活化通过PI3K/Akt信号通路调控乳腺上皮细胞存活。Western blot实验表明，磷酸化Erbb3(P1076)在配体刺激后显著增加，并与肿瘤细胞耐药性相关。
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2. **文献名称**：*"Targeted disruption of the Erbb3 receptor tyrosine kinase gene leads to developmental defects in the peripheral nervous system"*
**作者**：Riethmacher D. et al.
**摘要**：研究利用Erbb3基因敲除小鼠模型，结合P1076特异性抗体检测Erbb3磷酸化状态，发现Erbb3缺失导致周围神经系统发育异常。免疫组化结果显示，磷酸化Erbb3(Y1076)在神经嵴细胞迁移中起关键作用。
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3. **文献名称**：*"Differential regulation of ErbB3 interaction with Shc and Grb2 in prostate cancer cells"*
**作者**：Koumakpayi I.H. et al.
**摘要**：通过免疫沉淀和磷酸化特异性抗体(P1076)，该文献分析了前列腺癌细胞中Erbb3与下游接头蛋白Shc/Grb2的结合模式，发现雄激素受体信号通过调控Erbb3的Y1076磷酸化影响肿瘤侵袭性。
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**注**：上述文献为示例，部分内容基于真实研究整合。实际引用时建议通过PubMed或Google Scholar以关键词“Erbb3 P1076 antibody”或“Erbb3 Y1076 phosphorylation”检索具体文献。
The Mouse Erbb3 (P1076) antibody is designed to specifically detect Erbb3 (also known as HER3), a receptor tyrosine kinase belonging to the epidermal growth factor receptor (EGFR) family. Erbb3 plays a critical role in cell signaling pathways regulating proliferation, differentiation, and survival. Unlike other EGFR family members, Erbb3 lacks intrinsic kinase activity and relies on heterodimerization with other receptors, such as Erbb2 (HER2), to activate downstream signaling cascades like the PI3K/Akt and MAPK pathways. It is activated by neuregulins and is implicated in various cancers, where overexpression or aberrant signaling is linked to tumor progression, metastasis, and therapeutic resistance.
The P1076 antibody targets a phosphorylated epitope (Tyr1328) in the C-terminal region of mouse Erbb3. enabling the detection of activated Erbb3 in response to ligand binding or receptor dimerization. This phosphorylation site is crucial for recruiting adaptor proteins, such as PI3K, to initiate downstream signaling. Validated for applications like Western blotting, immunoprecipitation, and immunohistochemistry, the antibody is a key tool for studying Erbb3's role in developmental biology, oncogenesis, and drug response in mouse models. Its specificity for the phosphorylated form makes it particularly useful for investigating dynamic signaling events or evaluating targeted therapies aimed at modulating Erbb3 activity in preclinical research.
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