| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | KNS; KINH; KNS1; UKHC; HEL-S-61 |
| Entrez GeneID | 3799 |
| WB Predicted band size | Calculated MW: 110 kDa; Observed MW: 110 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human KIF5B |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于PLXNB1抗体的3篇代表性文献的简要信息：
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1. **文献名称**：*PLXNB1 promotes glioblastoma progression by activating AKT/mTOR signaling*
**作者**：Zhang Y, et al.
**摘要**：该研究通过免疫组化(使用PLXNB1抗体)发现，PLXNB1在胶质母细胞瘤中高表达，并通过激活AKT/mTOR通路促进肿瘤增殖和侵袭。实验表明，靶向PLXNB1可抑制小鼠模型中的肿瘤生长。
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2. **文献名称**：*Plexin-B1 regulates axon guidance through RhoA-dependent signaling*
**作者**：Matsuda K, et al.
**摘要**：研究利用PLXNB1抗体进行免疫荧光染色，发现其在神经元轴突导向中通过调控RhoA信号通路发挥作用。体外实验显示，PLXNB1缺失导致神经元迁移异常，提示其在中枢神经系统发育中的关键角色。
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3. **文献名称**：*Anti-PLXNB1 antibody inhibits tumor metastasis by disrupting angiogenesis*
**作者**：Jones RL, et al.
**摘要**：该团队开发了一种靶向PLXNB1的单克隆抗体，通过阻断其与血管内皮生长因子受体(VEGFR)的相互作用，显著抑制肿瘤血管生成和转移。动物模型显示抗体治疗可延长生存期。
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*注：上述文献为示例性内容，实际研究中请通过学术数据库(如PubMed、Web of Science)检索具体文献。*
PLXNB1 (Plexin B1) is a transmembrane receptor belonging to the plexin family, which plays a critical role in mediating cellular signaling pathways involved in cell migration, axon guidance, and tissue morphogenesis. It primarily interacts with semaphorins, particularly Sema4D (SEMA4D/CD100), to regulate processes such as cytoskeletal reorganization and cell-cell communication. PLXNB1 is also known to crosstalk with the Met proto-oncogene and activate downstream effectors like Rho family GTPases, influencing cell adhesion, proliferation, and invasion. Dysregulation of PLXNB1 has been implicated in various pathologies, including cancer progression, metastasis, and angiogenesis, as well as neurological disorders characterized by impaired neural circuit formation.
Antibodies targeting PLXNB1 are essential tools for studying its expression, localization, and function in both physiological and disease contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, flow cytometry, and immunofluorescence to investigate PLXNB1’s role in tumor microenvironments, neuronal development, and immune responses. Commercial PLXNB1 antibodies are typically validated for specificity against human, mouse, or rat homologs, with applications spanning basic research and therapeutic development. Their utility extends to biomarker studies in cancers (e.g., glioblastoma, breast, and prostate cancers) and neurological conditions, offering insights into potential diagnostic or therapeutic targets. Suppliers include major companies like R&D Systems, Abcam, and Santa Cruz Biotechnology.
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